Gene
limk1a
- ID
- ZDB-GENE-061212-3
- Name
- LIM domain kinase 1a
- Symbol
- limk1a Nomenclature History
- Previous Names
-
- limk1
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within response to yeast. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm; neuron projection; and nucleus. Is expressed in several structures, including blood vessel; brain; digestive system; eye; and fin. Orthologous to human LIMK1 (LIM domain kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Actin-regulating Serine/Threonine Kinase | PDZ domain | PDZ superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BHH8
|
628 | ||||||||
|
UniProtKB:Q0PWB7
|
648 | ||||||||
|
UniProtKB:A0A8M2BGY7
|
570 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
limk1a-201
(1)
|
Ensembl | 2,174 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-257O19 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194567 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001042691 (1) | 2024 nt | ||
| Genomic | GenBank:BX640522 (2) | 154564 nt | ||
| Polypeptide | UniProtKB:Q0PWB7 (1) | 648 aa |
- Messina, A., Boiti, A., Vallortigara, G. (2020) Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). The European journal of neuroscience. 53(2):362-375
- Lin, C.L., Taggart, A.J., Lim, K.H., Ferraris, L., Cygan, K.J., Creton, R., Huang, Y.T., Fairbrother, W.G. (2016) RNA structure replaces the need for U2AF65 in splicing. Genome research. 26(1):12-23
- Moriyama, Y., Ito, F., Takeda, H., Yano, T., Okabe, M., Kuraku, S., Keeley, F.W., Koshiba-Takeuchi, K. (2016) Evolution of the fish heart by sub/neofunctionalization of an elastin gene. Nature communications. 7:1039710397
- Wang, Y.C., Lin, C., Chuang, M.T., Hsieh, W.P., Lan, C.Y., Chuang, Y.J., and Chen, B.S. (2013) Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study. BMC systems biology. 7:79
- Ott, E.B., Te Velthuis, A.J., and Bagowski, C.P. (2007) Comparative analysis of splice form-specific expression of LIM Kinases during zebrafish development. Gene expression patterns : GEP. 7(5):620-629
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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