Gene
shank2b
- ID
- ZDB-GENE-061207-58
- Name
- SH3 and multiple ankyrin repeat domains 2b
- Symbol
- shank2b Nomenclature History
- Previous Names
-
- shank2
- si:dkey-221m4.1
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have GKAP/Homer scaffold activity and ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including nervous system development; positive regulation of synaptic transmission; and regulation of AMPA receptor activity. Predicted to colocalize with ionotropic glutamate receptor complex and postsynaptic membrane. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human SHANK2 (SH3 and multiple ankyrin repeat domains 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Autism susceptibility 17} | 613436 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR001660 | Sterile alpha motif domain |
| Domain | IPR032425 | Talin, N-terminal F0 domain |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| Repeat | IPR002110 | Ankyrin repeat |
Domain Details Per Protein
| Protein | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | PDZ domain | PDZ superfamily | SH3 domain | SH3-like domain superfamily | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily | Talin, N-terminal F0 domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B750
|
1440 | |||||||||
|
UniProtKB:A0A8M9P6G4
|
1810 | |||||||||
|
UniProtKB:A0A8M3AP18
|
1803 | |||||||||
|
UniProtKB:A0A8M3APN7
|
1235 | |||||||||
|
UniProtKB:A2AV32
|
1800 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
shank2-201
(1)
|
Havana | 5411 nt |
Interactions and Pathways
No data available
Plasmids
No data available