Gene
tacr3l
- ID
- ZDB-GENE-061207-19
- Name
- tachykinin receptor 3-like
- Symbol
- tacr3l Nomenclature History
- Previous Names
-
- tacr3a2 (1)
- tacr3b
- si:ch211-217k17.1
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables tachykinin receptor activity. Predicted to be involved in positive regulation of flagellated sperm motility. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane and sperm midpiece. Is expressed in several structures, including adipose tissue; brain; liver; pleuroperitoneal region; and retina. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 11 with or without anosmia. Orthologous to human TACR3 (tachykinin receptor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tacr3l | China Zebrafish Resource Center (CZRC) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 11 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 11 with or without anosmia | 614840 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Neurokinin NK3 receptor | Neurokinin receptor |
|---|---|---|---|---|---|---|
| UniProtKB:F1R3V0 | InterPro | 395 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tacr3l-201
(1)
|
Ensembl | 3,875 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-217K17 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001256635 (1) | 1188 nt | ||
| Genomic | GenBank:BX323839 (1) | 155358 nt | ||
| Polypeptide | UniProtKB:F1R3V0 (1) | 395 aa |
- Pandey, S., Shekhar, K., Regev, A., Schier, A.F. (2018) Comprehensive Identification and Spatial Mapping of Habenular Neuronal Types Using Single-Cell RNA-Seq. Current biology : CB. 28(7):1052-1065.e7
- Guillot, R., Cortés, R., Navarro, S., Mischitelli, M., García-Herranz, V., Sánchez, E., Cal, L., Navarro, J.C., Míguez, J., Afanasyev, S., Krasnov, A., Cone, R.D., Rotllant, J., Cerdá-Reverter, J.M. (2016) Behind melanocortin antagonist overexpression in the zebrafish brain: A behavioral and transcriptomic approach. Hormones and behavior. 82:87-100
- Qi, X., Salem, M., Zhou, W., Sato-Shimizu, M., Ye, G., Smitz, J., Peng, C. (2016) Neurokinin B Exerts Direct Effects on the Ovary to Stimulate Estradiol Production. Endocrinology. 157:3355-65
- López-Bellido, R., Barreto-Valer, K., and Rodriguez, R.E. (2013) Expression of tachykinin receptors in zebrafish: influence of cocaine and opioid receptors. Journal of molecular endocrinology. 50(2):115-129
- Biran, J., Palevitch, O., Ben-Dor, S., and Levavi-Sivan, B. (2012) Neurokinin Bs and neurokinin B receptors in zebrafish-potential role in controlling fish reproduction. Proceedings of the National Academy of Sciences of the United States of America. 109(26):10269-10274
- Zhou, W., Li, S., Liu, Y., Qi, X., Chen, H., Cheng, C.H., Liu, X., Zhang, Y., and Lin, H. (2012) The evolution of tachykinin/tachykinin receptor (TAC/TACR) in vertebrates and molecular identification of the TAC3/TACR3 system in zebrafish (Danio rerio). Molecular and Cellular Endocrinology. 361(1-2):202-212
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