Gene
smpd5
- ID
- ZDB-GENE-061110-22
- Name
- sphingomyelin phosphodiesterase 5
- Symbol
- smpd5 Nomenclature History
- Previous Names
-
- smpdm
- Mitochondrial SMase (1)
- zgc:153995
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables sphingomyelin phosphodiesterase activity. Acts upstream of or within glycosphingolipid metabolic process. Located in mitochondrial intermembrane space. Orthologous to human SMPD5 (sphingomyelin phosphodiesterase 5 (pseudogene)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa22962 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Endonuclease/exonuclease/phosphatase | Endonuclease/exonuclease/phosphatase superfamily | Sphingomyelinase C/phospholipase C | Sphingomyelinase C/Sphingomyelin phosphodiesterase 2-like |
|---|---|---|---|---|---|
|
UniProtKB:F1QG30
|
545 | ||||
|
UniProtKB:A0A2R8Q7Q7
|
545 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-199L17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153995 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174209 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192488 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077615 (1) | 2203 nt | ||
| Genomic | GenBank:CR759845 (1) | 181187 nt | ||
| Polypeptide | UniProtKB:A0A2R8Q7Q7 (1) | 545 aa |
- Rajagopalan, V., Canals, D., Luberto, C., Snider, J., Voelkel-Johnson, C., Obeid, L.M., Hannun, Y.A. (2015) Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization. Biochimica et biophysica acta. 1850:628-39
- Wu, B.X., Rajagopalan, V., Roddy, P.L., Clarke, C.J., and Hannun, Y.A. (2010) Identification and characterization of murine mitochondrial-associated neutral sphingomyelinase (ma-nsmase), the mammalian sphingomyelin phosphodiesterase 5. The Journal of biological chemistry. 285(23):17993-18002
- Yabu, T., Shimizu, A., and Yamashita, M. (2009) A novel mitochondrial sphingomyelinase in zebrafish cells. The Journal of biological chemistry. 284(30):20349-20363
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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