Gene

rbl2

ID

ZDB-GENE-061109-2

Name

retinoblastoma-like 2 (p130)

Symbol

rbl2 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have RNA polymerase II activating transcription factor binding activity and RNA polymerase II regulatory region DNA binding activity. Predicted to be involved in cell differentiation and negative regulation of G1/S transition of mitotic cell cycle. Predicted to localize to chromatin and transcription factor complex. Is expressed in neuromast. Orthologous to human RBL2 (RB transcriptional corepressor like 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rbl2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Brunet-Wagner neurodevelopmental syndrome	619690

Associated With rbl2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002719	Retinoblastoma-associated protein, B-box
Domain	IPR002720	Retinoblastoma-associated protein, A-box
Domain	IPR013763	Cyclin-like domain
Domain	IPR015030	Retinoblastoma-associated protein, C-terminal
Domain	IPR024599	Retinoblastoma-associated protein, N-terminal
Family	IPR028309	Retinoblastoma protein family
Homologous_superfamily	IPR036915	Cyclin-like superfamily

Domain Details Per Protein

Protein	Length	Cyclin-like domain	Cyclin-like superfamily	Retinoblastoma-associated protein, A-box	Retinoblastoma-associated protein, B-box	Retinoblastoma-associated protein, C-terminal	Retinoblastoma-associated protein, N-terminal	Retinoblastoma protein family
UniProtKB:A0A8M2BA88 InterPro	897
UniProtKB:A0A8M3AZW2 InterPro	1078
UniProtKB:E7FDM3 InterPro	1079

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rbl2-201 (1) Ensembl	Havana	7252 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations