ZFIN is now using GRCz12tu for Genomic Data
Gene
adcy2a
- ID
- ZDB-GENE-061109-1
- Name
- adenylate cyclase 2a
- Symbol
- adcy2a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable adenylate cyclase activity. Acts upstream of or within atrioventricular canal development and determination of heart left/right asymmetry. Predicted to be located in cytoplasm and membrane. Predicted to be active in plasma membrane. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human ADCY2 (adenylate cyclase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Izarzugaza et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| congenital heart disease | AB/TL + MO1-adcy2a | standard conditions | Izarzugaza et al., 2020 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018297 | Adenylyl cyclase class-4/guanylyl cyclase, conserved site |
| Domain | IPR001054 | Adenylyl cyclase class-3/4/guanylyl cyclase |
| Domain | IPR009398 | Adenylate cyclase, conserved domain |
| Domain | IPR032628 | Adenylate cyclase, N-terminal |
| Family | IPR030672 | Adenylate cyclase |
| Homologous_superfamily | IPR029787 | Nucleotide cyclase |
Domain Details Per Protein
| Protein | Additional Resources | Length | Adenylate cyclase | Adenylate cyclase, conserved domain | Adenylate cyclase, N-terminal | Adenylyl cyclase class-3/4/guanylyl cyclase | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | Nucleotide cyclase |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PC26 | InterPro | 197 | ||||||
| UniProtKB:A0A8N7TBA8 | InterPro | 1155 | ||||||
| UniProtKB:A0A8M9NZK7 | InterPro | 1101 | ||||||
| UniProtKB:A0A8M2B4W1 | InterPro | 900 | ||||||
| UniProtKB:A0AC58HIR2 | InterPro | 813 | ||||||
| UniProtKB:A0AC58HIV5 | InterPro | 885 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adcy2a-201
(1)
|
Ensembl | 4,102 nt | ||
| mRNA |
adcy2a-202
(1)
|
Ensembl | 3,267 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers