Gene
telo2
- ID
- ZDB-GENE-061103-523
- Name
- TEL2, telomere maintenance 2, homolog (S. cerevisiae)
- Symbol
- telo2 Nomenclature History
- Previous Names
-
- si:ch211-153c20.2
- zgc:153824 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable Hsp90 protein binding activity and telomeric DNA binding activity. Acts upstream of or within liver regeneration. Predicted to be located in cytoplasm; membrane; and nucleus. Predicted to be active in cytosol. Is expressed in peripheral olfactory organ. Orthologous to human TELO2 (telomere maintenance 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-telo2 | Zhang et al., 2022 | |
| CRISPR2-telo2 | Shin et al., 2021 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| You-Hoover-Fong syndrome | 616954 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | TEL2, C-terminal domain superfamily | Telomere length regulation protein, conserved domain | Telomere Length Regulation TEL2 |
|---|---|---|---|---|
|
UniProtKB:Q7T006
|
822 | |||
|
UniProtKB:A0A2R8RJV5
|
816 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:telo2-GFP,cryaa:Venus) |
| 1 | Zhang et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-153C20 | ||
| Encodes | cDNA | MGC:153824 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077741 (1) | 3010 nt | ||
| Genomic | GenBank:AL772148 (1) | 161218 nt | ||
| Polypeptide | UniProtKB:Q7T006 (1) | 822 aa |
- Zhang, J., Zhou, Y., Li, S., Mo, D., Ma, J., Ni, R., Yang, Q., He, J., Luo, L. (2022) Tel2 regulates redifferentiation of bipotential progenitor cells via Hhex during zebrafish liver regeneration. Cell Reports. 39:110596
- Liu, D., Alhazmi, N., Matthews, H., Lee, M.K., Li, J., Hecht, J.T., Wehby, G.L., Moreno, L.M., Heike, C.L., Roosenboom, J., Feingold, E., Marazita, M.L., Claes, P., Liao, E.C., Weinberg, S.M., Shaffer, J.R. (2021) Impact of low-frequency coding variants on human facial shape. Scientific Reports. 11:748
- Shin, U., Nakhro, K., Oh, C.K., Carrington, B., Song, H., Varshney, G.K., Kim, Y., Song, H., Jeon, S., Robbins, G., Kim, S., Yoon, S., Choi, Y.J., Kim, Y.J., Burgess, S., Kang, S., Sood, R., Lee, Y., Myung, K. (2021) Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. DNA repair. 107:103173
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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