Gene
cyp2aa2
- ID
- ZDB-GENE-061027-232
- Name
- y cytochrome P450, family 2, subfamily AA, polypeptide 2
- Symbol
- cyp2aa2 Nomenclature History
- Previous Names
-
- zgc:153597
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in female organism; liver; and male organism.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450, E-class, group I, CYP2D-like | Cytochrome P450 family 2 | Cytochrome P450 superfamily |
---|---|---|---|---|---|---|---|
UniProtKB:Q05AM2
|
498 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
cyp2aa2-201
(1)
|
Ensembl | 1,823 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-12M15 | ZFIN Curated Data | |
Encodes | cDNA | MGC:153597 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192708 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001077458 (1) | 1821 nt | ||
Genomic | GenBank:CU013526 (2) | 111595 nt | ||
Polypeptide | UniProtKB:Q05AM2 (1) | 498 aa |
No data available
- Pípal, M., Legradi, J., Smutná, M., Kočí, T., Priebojová, J., Bláhová, L., Krauss, M., Hilscherová, K. (2020) Neurobehavioral effects of cyanobacterial biomass field extracts on zebrafish embryos and potential role of retinoids. Aquatic toxicology (Amsterdam, Netherlands). 228:105613
- He, Y., Sun, C., Zhang, Y., Folkerts, E.J., Martin, J.W., Goss, G.G. (2018) Developmental Toxicity of the Organic Fraction from Hydraulic Fracturing Flowback and Produced Waters to Early Life Stages of Zebrafish (Danio rerio). Environmental science & technology. 52(6):3820-3830
- Shi, X.C., Sun, J., Jin, A., Ji, H., Yu, H.B., Li, Y., Li, X.X., Liu, P., Li, C., Huang, J.Q. (2018) Cytochrome P450 2AA molecular clone, expression pattern, and different regulation by fish oil and lard oil in diets of grass carp (Ctenopharyngodon idella). Fish physiology and biochemistry. 44(4):1019-1026
- Puthumana, J., Kim, B.M., Jeong, C.B., Kim, D.H., Kang, H.M., Jung, J.H., Kim, I.C., Hwang, U.K., Lee, J.S. (2017) Nine co-localized cytochrome P450 genes of the CYP2N, CYP2AD, and CYP2P gene families in the mangrove killifish Kryptolebias marmoratus genome: Identification and expression in response to B[α]P, BPA, OP, and NP. Aquatic toxicology (Amsterdam, Netherlands). 187:132-140
- Yang, Y., Ji, D., Huang, X., Zhang, J., Liu, J. (2017) Effects of metals on enantioselective toxicity and biotransformation of cis-bifenthrin in zebrafish. Environmental toxicology and chemistry. 36(8):2139-2146
- Lemaire, B., Kubota, A., O'Meara, C.M., Lamb, D.C., Tanguay, R.L., Goldstone, J.V., Stegeman, J.J. (2016) Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders. Toxicology and applied pharmacology. 296:73-84
- Kubota, A., Goldstone, J.V., Lemaire, B., Takata, M., Woodin, B.R., Stegeman, J.J. (2015) Pregnane X Receptor and Aryl Hydrocarbon Receptor Both Are Involved in Transcriptional Regulation of pxr, CYP2 and CYP3 Genes in Developing Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 143(2):398-407
- Kubota, A., Bainy, A.C., Woodin, B.R., Goldstone, J.V., and Stegeman, J.J. (2013) The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): Expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers. Toxicology and applied pharmacology. 272(1):172-9
- Yuan, L., Lv, B., Zha, J., Wang, Z., Wang, W., Li, W., and Zhu, L. (2013) New cytochrome P450 1B1, 1C1, 2Aa, 2Y3, and 2K genes from Chinese rare minnow (Gobiocypris rarus): Molecular characterization, basal expression and response of rare minnow CYP1s and CYP2s mRNA exposed to the AHR agonist benzo[a]pyrene. Chemosphere. 93(2):209-16
- Kirischian, N., McArthur, A.G., Jesuthasan, C., Krattenmacher, B., and Wilson, J.Y. (2011) Phylogenetic and Functional Analysis of the Vertebrate Cytochrome P450 2 Family. Journal of molecular evolution. 72(1):56-71
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