Gene

kif6

ID

ZDB-GENE-061027-130

Name

kinesin family member 6

Symbol

kif6 Nomenclature History

Previous Names

skolios (1)
zgc:152746 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within spinal cord development. Located in ciliary base. Is expressed in brain; intestine; ovary; and testis. Used to study idiopathic scoliosis. Human ortholog(s) of this gene implicated in artery disease (multiple) and type 2 diabetes mellitus. Orthologous to human KIF6 (kinesin family member 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kif6 Human Ortholog

No data available

Associated With kif6 Via Experimental Models

Human Disease	Fish	Conditions	Citations
idiopathic scoliosis	kif6^gw328/gw328	standard conditions	Buchan et al., 2014
idiopathic scoliosis	kif6^gw326/gw326	standard conditions	(2)
idiopathic scoliosis	kif6^gw329/gw329	standard conditions	Buchan et al., 2014
idiopathic scoliosis	kif6^gw327/gw327	standard conditions	Buchan et al., 2014

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019821	Kinesin motor domain, conserved site
Domain	IPR001752	Kinesin motor domain
Family	IPR027640	Kinesin-like protein
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily