Gene
kif6
- ID
- ZDB-GENE-061027-130
- Name
- kinesin family member 6
- Symbol
- kif6 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within spinal cord development. Located in ciliary base. Is expressed in brain; intestine; ovary; and testis. Used to study idiopathic scoliosis. Human ortholog(s) of this gene implicated in artery disease (multiple) and type 2 diabetes mellitus. Orthologous to human KIF6 (kinesin family member 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| gw326 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| gw327 | Allele with one deletion | Exon 2 | Unknown | TALEN | |
| gw328 | Allele with one deletion | Exon 2 | Unknown | TALEN | |
| gw329 | Allele with one deletion | Exon 2 | Unknown | TALEN | |
| sa36522 | Allele with one point mutation | Unknown | Splice Site, Premature Stop | ENU | |
| sa36523 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43002 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
| stl95 | Allele with one point mutation | Unknown | Unknown | ENU | |
| ut20 | Allele with multiple variants | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-kif6 | Gray et al., 2020 | |
| CRISPR2-kif6 | Gray et al., 2020 | |
| MO1-kif6 | N/A | Choksi et al., 2014 |
| MO2-kif6 | N/A | Buchan et al., 2014 |
| MO3-kif6 | N/A | Buchan et al., 2014 |
| TALEN1-kif6 | (3) |
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Human Disease
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
| Domain | IPR001752 | Kinesin motor domain |
| Family | IPR027640 | Kinesin-like protein |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Kinesin-like protein | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q05AP4 | InterPro | 667 | |||||
| UniProtKB:A0AB13A9F9 | InterPro | 761 | |||||
| UniProtKB:A0AB32T5K2 | InterPro | 744 | |||||
| UniProtKB:A0AB32T627 | InterPro | 741 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-264H24 | ZFIN Curated Data | |
| Contained in | BAC | CH73-309K8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152746 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192807 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423671 (1) | 2875 nt | ||
| Genomic | GenBank:BX901925 (1) | 187245 nt | ||
| Polypeptide | UniProtKB:A0AB13A9F9 (1) | 761 aa |
- Gray, R.S., Gonzalez, R., Ackerman, S.D., Minowa, R., Griest, J.F., Bayrak, M.N., Troutwine, B., Canter, S., Monk, K.R., Sepich, D.S., Solnica-Krezel, L. (2020) Postembryonic screen for mutations affecting spine development in zebrafish. Developmental Biology. 471:18-33
- Troutwine, B.R., Gontarz, P., Konjikusic, M.J., Minowa, R., Monstad-Rios, A., Sepich, D.S., Kwon, R.Y., Solnica-Krezel, L., Gray, R.S. (2020) The Reissner Fiber Is Highly Dynamic In Vivo and Controls Morphogenesis of the Spine. Current biology : CB. 30(12):2353-2362.e3
- Konjikusic, M.J., Yeetong, P., Boswell, C.W., Lee, C., Roberson, E.C., Ittiwut, R., Suphapeetiporn, K., Ciruna, B., Gurnett, C.A., Wallingford, J.B., Shotelersuk, V., Gray, R.S. (2018) Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development. PLoS Genetics. 14:e1007817
- Boswell, C.W., Ciruna, B. (2017) Understanding Idiopathic Scoliosis: A New Zebrafish School of Thought. Trends in genetics : TIG. 33(3):183-196
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Buchan, J.G., Gray, R.S., Gansner, J.M., Alvarado, D.M., Burgert, L., Gitlin, J.D., Gurnett, C.A., Goldsmith, M.I. (2014) Kinesin family member 6 (kif6) is necessary for spine development in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 243(12):1646-57
- Choksi, S.P., Babu, D., Lau, D., Yu, X., Roy, S. (2014) Systematic discovery of novel ciliary genes through functional genomics in the zebrafish. Development (Cambridge, England). 141:3410-9
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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