Gene

usp9

ID

ZDB-GENE-061019-1

Name

ubiquitin specific peptidase 9

Symbol

usp9 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in cell migration and regulation of protein stability. Predicted to act upstream of or within protein deubiquitination and proteolysis. Predicted to be active in cytosol and nucleus. Is expressed in endodermal cell; myotome; nervous system; pectoral fin; and solid lens vesicle. Human ortholog(s) of this gene implicated in Y-linked spermatogenic failure 2; female-restricted syndromic X-linked intellectual disability 99; and non-syndromic X-linked intellectual disability 99. Orthologous to several human genes including USP9X (ubiquitin specific peptidase 9 X-linked).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Khut et al., 2007

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Köglsberger et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With usp9 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
female-restricted syndromic X-linked intellectual disability 99	Alliance	Intellectual developmental disorder, X-linked 99, syndromic, female-restricted	300968
non-syndromic X-linked intellectual disability 99	Alliance	Intellectual developmental disorder, X-linked 99	300919
Y-linked spermatogenic failure 2	Alliance	Spermatogenic failure, Y-linked, 2	415000

Associated With usp9 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018200	Ubiquitin specific protease, conserved site
Domain	IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Domain	IPR021905	Ubiquitin C-terminal hydrolase-like, DUF3517
Domain	IPR028889	Ubiquitin specific protease domain
Domain	IPR055176	UBP24/USP9X/USP9Y, ubiquitin-like domain
Family	IPR050164	Ubiquitin carboxyl-terminal hydrolases
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily

Domain Details Per Protein

Protein	Length	Armadillo-type fold	Papain-like cysteine peptidase superfamily	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	Ubiquitin carboxyl-terminal hydrolases	Ubiquitin C-terminal hydrolase-like, DUF3517	Ubiquitin specific protease, conserved site	Ubiquitin specific protease domain	UBP24/USP9X/USP9Y, ubiquitin-like domain
UniProtKB:Q4FE55 InterPro	2551
UniProtKB:A0A8M3AW48 InterPro	2557
UniProtKB:A0A8M3B5Q3 InterPro	2593
UniProtKB:A0A8M3B2R0 InterPro	2558
UniProtKB:A0A8M2BF50 InterPro	2594