Gene
odad3
- ID
- ZDB-GENE-061013-787
- Name
- outer dynein arm docking complex subunit 3
- Symbol
- odad3 Nomenclature History
- Previous Names
-
- ccdc151
- flanders
- unm ts272
- unm_ts272
- zgc:152917
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Involved in axonemal dynein complex assembly; cilium movement; and determination of left/right symmetry. Acts upstream of or within several processes, including Kupffer's vesicle development; determination of left/right symmetry; and microtubule cytoskeleton organization. Located in ciliary basal body and motile cilium. Is expressed in several structures, including Kupffer's vesicle; forerunner cell group; intermediate mesoderm; nervous system; and pronephros. Used to study idiopathic scoliosis and primary ciliary dyskinesia. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 30. Orthologous to human ODAD3 (outer dynein arm docking complex subunit 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ciliary dyskinesia 30 | Alliance | Ciliary dyskinesia, primary, 30 | 616037 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| idiopathic scoliosis | odad3ts272/ts272 | standard conditions | Rose et al., 2020 |
| primary ciliary dyskinesia | odad3ts272/ts272 | standard conditions | Song et al., 2016 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ODAD1, central coiled coil region | Outer dynein arm-docking complex subunit 3 |
|---|---|---|---|---|
| UniProtKB:F1QFD6 | InterPro | 545 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ccdc151-201
(1)
|
Ensembl | 1,846 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-276A17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152917 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077369 (1) | 1845 nt | ||
| Genomic | GenBank:AL772339 (1) | 166809 nt | ||
| Polypeptide | UniProtKB:F1QFD6 (1) | 545 aa |
- Lu, H., Twan, W.K., Ikawa, Y., Khare, V., Mukherjee, I., Schou, K.B., Chua, K.X., Aqasha, A., Chakrabarti, S., Hamada, H., Roy, S. (2024) Localisation and function of key axonemal microtubule inner proteins and dynein docking complex members reveal extensive diversity among vertebrate motile cilia. Development (Cambridge, England). 151(14):
- Rose, C.D., Pompili, D., Henke, K., Van Gennip, J.L.M., Meyer-Miner, A., Rana, R., Gobron, S., Harris, M.P., Nitz, M., Ciruna, B. (2020) SCO-Spondin Defects and Neuroinflammation Are Conserved Mechanisms Driving Spinal Deformity across Genetic Models of Idiopathic Scoliosis. Current biology : CB. 30(12):2363-2373.e6
- Grimes, D.T., Boswell, C.W., Morante, N.F., Henkelman, R.M., Burdine, R.D., Ciruna, B. (2016) Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature. Science (New York, N.Y.). 352:1341-4
- Song, Z., Zhang, X., Jia, S., Yelick, P.C., Zhao, C. (2016) Zebrafish as a Model for Human Ciliopathies. Journal of genetics and genomics = Yi chuan xue bao. 43:107-20
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Hjeij, R., Onoufriadis, A., Watson, C.M., Slagle, C.E., Klena, N.T., Dougherty, G.W., Kurkowiak, M., Loges, N.T., Diggle, C.P., Morante, N.F., Gabriel, G.C., Lemke, K.L., Li, Y., Pennekamp, P., Menchen, T., Konert, F., Marthin, J.K., Mans, D.A., Letteboer, S.J., Werner, C., Burgoyne, T., Westermann, C., Rutman, A., Carr, I.M., O'Callaghan, C., Moya, E., Chung, E.M., UK10K Consortium, Sheridan, E., Nielsen, K.G., Roepman, R., Bartscherer, K., Burdine, R.D., Lo, C.W., Omran, H., Mitchison, H.M. (2014) CCDC151 Mutations Cause Primary Ciliary Dyskinesia by Disruption of the Outer Dynein Arm Docking Complex Formation. American journal of human genetics. 95:257-274
- Jerber, J., Baas, D., Soulavie, F., Chhin, B., Cortier, E., Vesque, C., Thomas, J., and Durand, B. (2014) The coiled-coil domain containing protein CCDC151 is required for the function of IFT-dependent motile cilia in animals. Human molecular genetics. 23(3):563-77
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
- Brand, M., Heisenberg, C.P., Warga, R.M., Pelegri, F., Karlstrom, R.O., Beuchle, D., Picker, A., Jiang, Y.J., Furutani-Seiki, M., van Eeden, F.J., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. Development (Cambridge, England). 123:129-142
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