Gene
ttll11
- ID
- ZDB-GENE-061013-747
- Name
- tubulin tyrosine ligase-like family, member 11
- Symbol
- ttll11 Nomenclature History
- Previous Names
-
- zgc:153539
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Acts upstream of or within chromosome segregation and retinal cone cell development. Predicted to be active in ciliary basal body. Orthologous to human TTLL11 (tubulin tyrosine ligase like 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zadra et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR004344 | Tubulin-tyrosine ligase/Tubulin polyglutamylase |
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Domain Details Per Protein
| Protein | Length | Tubulin-tyrosine ligase/Tubulin polyglutamylase |
|---|---|---|
|
UniProtKB:Q08BJ4
|
723 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ttll11-201
(1)
|
Ensembl | 2,327 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-254O16 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-34E4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153539 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077375 (1) | 2319 nt | ||
| Genomic | GenBank:AL929337 (1) | 176736 nt | ||
| Polypeptide | UniProtKB:Q08BJ4 (1) | 723 aa |
- Zadra, I., Jimenez-Delgado, S., Anglada-Girotto, M., Segura-Morales, C., Compton, Z.J., Janke, C., Serrano, L., Ruprecht, V., Vernos, I. (2022) Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11. Nature communications. 13:71477147
- Mathieu, H., Patten, S.A., Aragon-Martin, J.A., Ocaka, L., Simpson, M., Child, A., Moldovan, F. (2021) Genetic variant of TTLL11 gene and subsequent ciliary defects are associated with idiopathic scoliosis in a 5-generation UK family. Scientific Reports. 11:11026
- Manchenkov, T., Pasillas, M.P., Haddad, G.G., Imam, F.B. (2015) Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. G3 (Bethesda). 5(6):1107-16
- Pathak, N., Austin, C.A., and Drummond, I.A. (2011) Tubulin tyrosine ligase like genes TTLL3 and TTLL6 maintain zebrafish cilia structure and motility. The Journal of biological chemistry. 286(13):11685-11695
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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