Gene
dpyda
- ID
- ZDB-GENE-061013-727
- Name
- dihydropyrimidine dehydrogenase a
- Symbol
- dpyda Nomenclature History
- Previous Names
-
- dpyda.1
- dpyda.2
- dpyda.3
- dpyda
- si:ch73-256e21.1 (1)
- zgc:153505
- zmp:0000000967
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including 4 iron, 4 sulfur cluster binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and metal ion binding activity. Predicted to be involved in 'de novo' UMP biosynthetic process and beta-alanine biosynthetic process. Predicted to act upstream of or within 'de novo' pyrimidine nucleobase biosynthetic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase).
- Genome Resources
- Note
-
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dihydropyrimidine dehydrogenase deficiency | Alliance | 5-fluorouracil toxicity | 274270 |
| dihydropyrimidine dehydrogenase deficiency | Alliance | Dihydropyrimidine dehydrogenase deficiency | 274270 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001295 | Dihydroorotate dehydrogenase, conserved site |
| Conserved_site | IPR017900 | 4Fe-4S ferredoxin, iron-sulphur binding, conserved site |
| Domain | IPR005720 | Dihydroorotate dehydrogenase, catalytic |
| Domain | IPR017896 | 4Fe-4S ferredoxin-type, iron-sulphur binding domain |
| Domain | IPR023753 | FAD/NAD(P)-binding domain |
| Domain | IPR028261 | Dihydroprymidine dehydrogenase domain II |
| Homologous_superfamily | IPR009051 | Alpha-helical ferredoxin |
| Homologous_superfamily | IPR013785 | Aldolase-type TIM barrel |
| Homologous_superfamily | IPR036188 | FAD/NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | 4Fe-4S ferredoxin, iron-sulphur binding, conserved site | 4Fe-4S ferredoxin-type, iron-sulphur binding domain | Aldolase-type TIM barrel | Alpha-helical ferredoxin | Dihydroorotate dehydrogenase, catalytic | Dihydroorotate dehydrogenase, conserved site | Dihydroprymidine dehydrogenase domain II | FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q08BJ9 | InterPro | 243 | |||||||||
| UniProtKB:A0A8M6YVM7 | InterPro | 1023 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dpyda.1-201
(1)
|
Ensembl | 1,076 nt | ||
| mRNA |
dpyda.1-202
(1)
|
Ensembl | 705 nt |
Interactions and Pathways
No data available
Plasmids
No data available