Gene

dpyda.1

ID

ZDB-GENE-061013-727

Name

dihydropyrimidine dehydrogenase a, tandem duplicate 1

Symbol

dpyda.1 Nomenclature History

Previous Names

dpyda
zgc:153505

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have iron-sulfur cluster binding activity. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dpyda.1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dihydropyrimidine dehydrogenase deficiency	Alliance	5-fluorouracil toxicity	274270
dihydropyrimidine dehydrogenase deficiency	Alliance	Dihydropyrimidine dehydrogenase deficiency	274270

Associated With dpyda.1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001295	Dihydroorotate dehydrogenase, conserved site
Conserved_site	IPR017900	4Fe-4S ferredoxin, iron-sulphur binding, conserved site
Domain	IPR005720	Dihydroorotate dehydrogenase, catalytic
Domain	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain
Domain	IPR023753	FAD/NAD(P)-binding domain
Domain	IPR028261	Dihydroprymidine dehydrogenase domain II
Homologous_superfamily	IPR009051	Alpha-helical ferredoxin
Homologous_superfamily	IPR013785	Aldolase-type TIM barrel
Homologous_superfamily	IPR036188	FAD/NAD(P)-binding domain superfamily