ZFIN is now using GRCz12tu for Genomic Data
Gene
dpyda
- ID
- ZDB-GENE-061013-727
- Name
- dihydropyrimidine dehydrogenase a
- Symbol
- dpyda Nomenclature History
- Previous Names
-
- dpyda.1
- dpyda.2
- dpyda.3
- dpyda
- si:ch73-256e21.1 (1)
- zgc:153505
- zmp:0000000967
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable NADP binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and uracil binding activity. Predicted to be involved in thymine catabolic process and uracil catabolic process. Predicted to act upstream of or within 'de novo' pyrimidine nucleobase biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dihydropyrimidine dehydrogenase deficiency | Alliance | 5-fluorouracil toxicity | 274270 |
| dihydropyrimidine dehydrogenase deficiency | Alliance | Dihydropyrimidine dehydrogenase deficiency | 274270 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha-helical ferredoxin | Dihydroprymidine dehydrogenase domain II | FAD/NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:Q08BJ9 | InterPro | 243 | |||
| UniProtKB:A0A8M6YVM7 | InterPro | 1023 | |||
| UniProtKB:A0AC58IS10 | InterPro | 270 | |||
| UniProtKB:A0AC58IS12 | InterPro | 302 | |||
| UniProtKB:A0AC58IS13 | InterPro | 576 | |||
| UniProtKB:A0AC58IS15 | InterPro | 1023 | |||
| UniProtKB:A0AC58IS16 | InterPro | 858 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dpyda.1-201
(1)
|
Ensembl | 1,076 nt | ||
| mRNA |
dpyda.1-202
(1)
|
Ensembl | 705 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers