Gene

pros1

ID

ZDB-GENE-061013-657

Name

protein S

Symbol

pros1 Nomenclature History

Previous Names

zgc:154001 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable calcium ion binding activity. Predicted to act upstream of or within blood coagulation and fibrinolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in hypochord. Human ortholog(s) of this gene implicated in autosomal dominant thrombophilia due to protein S deficiency; autosomal recessive thrombophilia due to protein S deficiency; cerebral infarction; and protein S deficiency. Orthologous to human PROS1 (protein S).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7158575 (3 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pros1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant thrombophilia due to protein S deficiency	Alliance	Thrombophilia 5 due to protein S deficiency, autosomal dominant	612336
autosomal recessive thrombophilia due to protein S deficiency	Alliance	Thrombophilia 5 due to protein S deficiency, autosomal recessive	614514

Associated With pros1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR013032	EGF-like, conserved site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000294	Gamma-carboxyglutamic acid-rich (GLA) domain
Domain	IPR000742	EGF-like domain
Domain	IPR001791	Laminin G domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR049883	NOTCH1 EGF-like calcium-binding domain
Family	IPR051145	Growth Arrest-Specific/Sex Hormone-Binding/Vitamin K-Dependent
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR017857	Coagulation factor-like, Gla domain superfamily
Homologous_superfamily	IPR035972	Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site

Domain Details Per Protein

Protein	Length	Coagulation factor-like, Gla domain superfamily	Concanavalin A-like lectin/glucanase domain superfamily	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like, conserved site	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	Gamma-carboxyglutamic acid-rich (GLA) domain	Gamma-carboxyglutamic acid-rich (GLA) domain superfamily	Growth Arrest-Specific/Sex Hormone-Binding/Vitamin K-Dependent	Growth factor receptor cysteine-rich domain superfamily	Laminin G domain	NOTCH1 EGF-like calcium-binding domain
UniProtKB:Q08BB9 InterPro	673

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pros1-201 (1) Ensembl	Ensembl	2,617 nt	Select Tool ZFIN BLAST
mRNA	pros1-203 (1) Ensembl	Ensembl	538 nt	Select Tool ZFIN BLAST
ncRNA	pros1-003 (1) Ensembl	Ensembl	852 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations