Gene

foxo1a

ID
ZDB-GENE-061013-59
Name
forkhead box O1 a
Symbol
foxo1a Nomenclature History
Previous Names
  • foxo1
  • foxo1a.1 (1)
  • zgc:153388
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including gluconeogenesis; lymph vessel development; and smooth muscle cell proliferation. Predicted to localize to nucleus. Is expressed in digestive system; head mesenchyme; pericardial region; and pharyngeal arch. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1).
Genome Resources
Note
None
Expression
All Expression Data
9 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Gays et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With foxo1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
alveolar rhabdomyosarcoma Alliance Rhabdomyosarcoma, alveolar 268220
Associated With foxo1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR030456 Fork head domain conserved site 2
Domain IPR001766 Fork head domain
Domain IPR032067 FOXO protein, transactivation domain
Domain IPR032068 FOXO protein, KIX-binding domain
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Fork head domain Fork head domain conserved site 2 FOXO protein, KIX-binding domain FOXO protein, transactivation domain Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:Q08BL0 268
UniProtKB:A3RK74 652
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations