Gene

foxo1a

ID

ZDB-GENE-061013-59

Name

forkhead box O1 a

Symbol

foxo1a Nomenclature History

Previous Names

foxo1
foxo1a.1 (1)
zgc:153388

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding activity; and transcription factor binding activity. Involved in lymph vessel development; smooth muscle cell proliferation; and smooth muscle tissue development. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Is expressed in digestive system; head mesenchyme; pericardial region; and pharyngeal arch. Orthologous to human FOXO1 (forkhead box O1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 11 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Gays et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With foxo1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
alveolar rhabdomyosarcoma	Alliance	Rhabdomyosarcoma, alveolar	268220

Associated With foxo1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR030456	Fork head domain conserved site 2
Domain	IPR001766	Fork head domain
Domain	IPR032067	FOXO protein, transactivation domain
Domain	IPR032068	FOXO protein, KIX-binding domain
Domain	IPR047408	Forkhead box protein O1, forkhead domain
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily