Gene
pkn2b
- ID
- ZDB-GENE-061013-393
- Name
- protein kinase N2b
- Symbol
- pkn2b Nomenclature History
- Previous Names
-
- zgc:153916
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within several processes, including cell adhesion; cell division; and protein phosphorylation. Predicted to be located in several cellular components, including cleavage furrow; lamellipodium; and midbody. Orthologous to human PKN2 (protein kinase N2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa19376 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24742 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32553 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38152 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44371 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45871 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR011072 | HR1 rho-binding domain |
| Domain | IPR017892 | Protein kinase, C-terminal |
| Domain | IPR037313 | Serine/threonine-protein kinase N, first HR1 domain |
| Domain | IPR037784 | Serine/threonine-protein kinase N, C2 domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR036274 | HR1 repeat superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | C2 domain | C2 domain superfamily | HR1 repeat superfamily | HR1 rho-binding domain | Protein kinase, ATP binding site | Protein kinase, C-terminal | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinase N, C2 domain | Serine/threonine-protein kinase N, first HR1 domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A7MBL8 | InterPro | 977 | ||||||||||||
| UniProtKB:A0A2R8RL78 | InterPro | 984 | ||||||||||||
| UniProtKB:Q08BD6 | InterPro | 339 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-128I1 | ZFIN Curated Data | |
| Contained in | BAC | CH211-180M24 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153916 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:165393 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001290179 (1) | 3972 nt | ||
| Genomic | RefSeq:NW_018394643 (1) | 372155 nt | ||
| Polypeptide | UniProtKB:A0A2R8RL78 (1) | 984 aa |
- Comparative Orthology
- Alliance
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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