Gene
cyp3c4
- ID
- ZDB-GENE-060929-96
- Name
- cytochrome P450, family 3, subfamily C, polypeptide 4
- Symbol
- cyp3c4 Nomenclature History
- Previous Names
-
- zgc:153269
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have steroid hydroxylase activity. Predicted to be involved in oxidation-reduction process. Predicted to localize to integral component of membrane. Is expressed in gill; heart; liver; nervous system; and pleuroperitoneal region.
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Cytochrome P450 | Cytochrome P450 3A | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 superfamily |
---|---|---|---|---|---|---|
UniProtKB:Q08CC5
|
507 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
cyp3c4-201
(1)
|
Ensembl | 2,309 nt | ||
mRNA |
cyp3c4-202
(1)
|
Ensembl | 2,292 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-21N8 | ZFIN Curated Data | |
Encodes | cDNA | MGC:153269 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001077548 (1) | 2337 nt | ||
Genomic | GenBank:BX649536 (1) | 203180 nt | ||
Polypeptide | UniProtKB:Q08CC5 (1) | 507 aa |
No data available
- Nawaji, T., Yamashita, N., Umeda, H., Zhang, S., Mizoguchi, N., Seki, M., Kitazawa, T., Teraoka, H. (2020) Cytochrome P450 Expression and Chemical Metabolic Activity before Full Liver Development in Zebrafish. Pharmaceuticals (Basel, Switzerland). 13(12):
- Wang, J., Jia, B., Li, Y., Ren, B., Liang, H., Yan, D., Xie, H., Zhang, X., Liang, H. (2020) Effects of multi-walled carbon nanotubes on the enantioselective toxicity of the chiral insecticide indoxacarb toward zebrafish (Danio rerio). Journal of hazardous materials. 397:122724
- Kubota, A., Kawai, Y.K., Yamashita, N., Lee, J.S., Kondoh, D., Zhang, S., Nishi, Y., Suzuki, K., Kitazawa, T., Teraoka, H. (2019) Transcriptional profiling of cytochrome P450 genes in the liver of adult zebrafish, Danio rerio. The Journal of Toxicological Sciences. 44:347-356
- Xu, C., Niu, L., Guo, H., Sun, X., Chen, L., Tu, W., Dai, Q., Ye, J., Liu, W., Liu, J. (2019) Long-term exposure to the non-steroidal anti-inflammatory drug (NSAID) naproxen causes thyroid disruption in zebrafish at environmentally relevant concentrations. The Science of the total environment. 676:387-395
- Shaya, L., Jones, D.E., Wilson, J.Y. (2018) CYP3C gene regulation by the aryl hydrocarbon and estrogen receptors in zebrafish. Toxicology and applied pharmacology. 362:77-85
- Yang, Y., Ji, D., Huang, X., Zhang, J., Liu, J. (2017) Effects of metals on enantioselective toxicity and biotransformation of cis-bifenthrin in zebrafish. Environmental toxicology and chemistry. 36(8):2139-2146
- Shaya, L., Dejong, C., Wilson, J.Y. (2014) Expression Patterns of Cytochrome P450 3B and 3C Genes in Model Fish Species. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 166:115-25
- David, R.M., Jones, H.S., Panter, G.H., Winter, M.J., Hutchinson, T.H., and Chipman, K.J. (2012) Interference with xenobiotic metabolic activity by the commonly used vehicle solvents dimethylsulfoxide and methanol in zebrafish (Danio rerio) larvae but not Daphnia magna. Chemosphere. 88(8):912-917
- Goldstone, J.V., McArthur, A.G., Kubota, A., Zanette, J., Parente, T., Jonsson, M.E., Nelson, D.R., and Stegeman, J.J. (2010) Identification and developmental expression of the full complement of cytochrome P450 genes in zebrafish. BMC Genomics. 11:643
- Jones, H.S., Panter, G.H., Hutchinson, T.H., and Chipman, J.K. (2010) Oxidative and conjugative xenobiotic metabolism in zebrafish larvae in vivo. Zebrafish. 7(1):23-30
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