Gene

tsen2

ID

ZDB-GENE-060929-918

Name

TSEN2 tRNA splicing endonuclease subunit

Symbol

tsen2 Nomenclature History

Previous Names

zgc:154067

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable tRNA-intron endonuclease activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to act upstream of or within mRNA processing and tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to be located in nucleus. Predicted to be part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2B. Orthologous to human TSEN2 (tRNA splicing endonuclease subunit 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tsen2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
pontocerebellar hypoplasia type 2B	Alliance	Pontocerebellar hypoplasia type 2B	612389

Associated With tsen2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006677	tRNA intron endonuclease, catalytic domain-like
Domain	IPR006678	tRNA intron endonuclease, N-terminal
Family	IPR006676	tRNA-splicing endonuclease
Family	IPR016589	tRNA-splicing endonuclease, SEN2 subunit
Homologous_superfamily	IPR011856	tRNA endonuclease-like domain superfamily
Homologous_superfamily	IPR036167	tRNA intron endonuclease, catalytic domain-like superfamily