Gene
nars2
- ID
- ZDB-GENE-060929-596
- Name
- asparaginyl-tRNA synthetase 2, mitochondrial
- Symbol
- nars2 Nomenclature History
- Previous Names
-
- zgc:153218
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable asparagine-tRNA ligase activity. Predicted to be involved in asparaginyl-tRNA aminoacylation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be active in mitochondrion. Is expressed in female organism. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 94 and combined oxidative phosphorylation deficiency 24. Orthologous to human NARS2 (asparaginyl-tRNA synthetase 2, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Newman et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 94 | Alliance | ?Deafness, autosomal recessive 94 | 618434 |
| combined oxidative phosphorylation deficiency 24 | Alliance | Combined oxidative phosphorylation deficiency 24 | 616239 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004364 | Aminoacyl-tRNA synthetase, class II (D/K/N) |
| Domain | IPR004365 | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type |
| Domain | IPR006195 | Aminoacyl-tRNA synthetase, class II |
| Family | IPR002312 | Aspartyl/Asparaginyl-tRNA synthetase, class IIb |
| Family | IPR004522 | Asparagine-tRNA ligase |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class II | Aminoacyl-tRNA synthetase, class II (D/K/N) | Asparagine-tRNA ligase | Aspartyl/Asparaginyl-tRNA synthetase, class IIb | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | Nucleic acid-binding, OB-fold | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q08CE2
|
485 | |||||||
|
UniProtKB:A0A8M9QLG1
|
505 |
Interactions and Pathways
No data available
Plasmids
No data available