Gene

seraf

ID

ZDB-GENE-060929-1226

Name

Schwann cell-specific EGF-like repeat autocrine factor

Symbol

seraf Nomenclature History

Previous Names

vwde (1)
zgc:153112

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to enable signaling receptor binding activity. Acts upstream of or within glial cell development and retina development in camera-type eye. Predicted to be active in cell surface and extracellular region. Orthologous to human VWDE (von Willebrand factor D and EGF domains).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Charlton-Perkins et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With seraf Human Ortholog

No data available

Associated With seraf Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Family	IPR050969	Developmental Signaling Modulators

Domain Details Per Protein

Protein	Length	Developmental Signaling Modulators	EGF-like domain
UniProtKB:A0A0R4IVA1 InterPro	212

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	vwde-201 (1) Ensembl	Ensembl		873 nt	Select Tool ZFIN BLAST
mRNA	vwde-202 (1) Ensembl	Ensembl		950 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations