Gene

dync1i2a

ID
ZDB-GENE-060929-1086
Name
dynein, cytoplasmic 1, intermediate chain 2a
Symbol
dync1i2a Nomenclature History
Previous Names
  • dync1i2
  • im:7147021
  • zgc:153318
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have dynein heavy chain binding activity and dynein light chain binding activity. Involved in mitotic spindle organization. Predicted to localize to cytoplasmic dynein complex. Used to study primary autosomal recessive microcephaly. Orthologous to human DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Ansar et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dync1i2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neurodevelopmental disorder with microcephaly and structural brain anomalies 618492
Associated With dync1i2a Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017986 WD40-repeat-containing domain
Family IPR025956 Cytoplasmic dynein 1 intermediate chain 1/2
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
Repeat IPR001680 WD40 repeat
Domain Details Per Protein
Protein Length Cytoplasmic dynein 1 intermediate chain 1/2 WD40 repeat WD40-repeat-containing domain WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A286YAG4 608
UniProtKB:E7F6H7 626
UniProtKB:Q08CA8 471
UniProtKB:A0A0R4IPR1 471
UniProtKB:A0A0R4IU59 326
UniProtKB:A0A0R4IHQ1 308
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations