Gene
mgp
- ID
- ZDB-GENE-060928-1
- Name
- matrix Gla protein
- Symbol
- mgp Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Predicted to act upstream of or within cartilage development; cell differentiation; and ossification. Predicted to be located in collagen-containing extracellular matrix and extracellular region. Predicted to be active in extracellular matrix. Is expressed in caudal fin; gill filament; heart; sensory system; and skeletal system. Human ortholog(s) of this gene implicated in arteriosclerosis; calcinosis; and myocardial infarction. Orthologous to human MGP (matrix Gla protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa39971 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Keutel syndrome | 245150 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Gamma-carboxyglutamic acid-rich (GLA) domain | Gamma-carboxyglutamic acid-rich (GLA) domain superfamily | Matrix Gla protein |
|---|---|---|---|---|---|
| UniProtKB:Q6YND0 | InterPro | 105 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-504D15 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194230 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194236 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205640 (1) | 643 nt | ||
| Genomic | GenBank:CU855786 (1) | 33341 nt | ||
| Polypeptide | UniProtKB:Q6YND0 (1) | 105 aa |
- Breuer, M., Rummler, M., Singh, J., Maher, S., Zaouter, C., Jamadagni, P., Pilon, N., Willie, B.M., Patten, S.A. (2024) CHD7 regulates craniofacial cartilage development via controlling HTR2B expression. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 39(4):498-512
- Nie, C.H., Wan, S.M., Chen, Y.L., Huysseune, A., Wu, Y.M., Zhou, J.J., Hilsdorf, A.W.S., Wang, W.M., Witten, P.E., Lin, Q., Gao, Z.X. (2022) Single-cell transcriptomes and runx2b-/- mutants reveal the genetic signatures of intermuscular bone formation in zebrafish. National science review. 9:nwac152nwac152
- Ma, H., Liu, Z., Yang, Y., Feng, D., Dong, Y., Garbutt, T.A., Hu, Z., Wang, L., Luan, C., Cooper, C.D., Li, Y., Welch, J.D., Qian, L., Liu, J. (2021) Functional coordination of non-myocytes plays a key role in adult zebrafish heart regeneration. EMBO reports. 22(11):e52901
- Granadeiro, L., Dirks, R.P., Ortiz-Delgado, J.B., Gavaia, P.J., Sarasquete, C., Laizé, V., Cancela, M.L., Fernández, I. (2019) Warfarin-exposed zebrafish embryos resembles human warfarin embryopathy in a dose and developmental-time dependent manner - From molecular mechanisms to environmental concerns. Ecotoxicology and environmental safety. 181:559-571
- Lopez-Baez, J.C., Simpson, D.J., LLeras Forero, L., Zeng, Z., Brunsdon, H., Salzano, A., Brombin, A., Wyatt, C., Rybski, W., Huitema, L.F.A., Dale, R.M., Kawakami, K., Englert, C., Chandra, T., Schulte-Merker, S., Hastie, N.D., Patton, E.E. (2018) Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair.. eLIFE. 7
- Palagano, E., Zuccarini, G., Prontera, P., Borgatti, R., Stangoni, G., Elisei, S., Mantero, S., Menale, C., Forlino, A., Uva, P., Oppo, M., Vezzoni, P., Villa, A., Merlo, G.R., Sobacchi, C. (2018) Mutations in the Neuroblastoma Amplified Sequence gene in a family affected by Acrofrontofacionasal Dysostosis type 1. Bone. 114:125-136
- Roberto, V.P., Gavaia, P., Nunes, M.J., Rodrigues, E., Cancela, M.L., Tiago, D.M. (2018) Evidences for a New Role of miR-214 in Chondrogenesis. Scientific Reports. 8:3704
- Fernández, I., Santos, A., Cancela, M.L., Laizé, V., Gavaia, P.J. (2014) Warfarin, a potential pollutant in aquatic environment acting through Pxr signaling pathway and γ-glutamyl carboxylation of vitamin K-dependent proteins. Environmental pollution (Barking, Essex : 1987). 194C:86-95
- Maradonna, F., Gioacchini, G., Falcinelli, S., Bertotto, D., Radaelli, G., Olivotto, I., and Carnevali, O. (2013) Probiotic Supplementation Promotes Calcification inDanio rerio Larvae: A Molecular Study. PLoS One. 8(12):e83155
- Chu, C.Y., Chen, C.F., Rajendran, R.S., Shen, C.N., Chen, T.H., Yen, C.C., Chuang, C.K., Lin, D.S., and Hsiao, C.D. (2012) Overexpression of akt1 enhances adipogenesis and leads to lipoma formation in zebrafish. PLoS One. 7(5):e36474
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