Gene
mybpc2a
- ID
- ZDB-GENE-060901-1
- Name
- myosin binding protein Ca
- Symbol
- mybpc2a Nomenclature History
- Previous Names
-
- zgc:136545
- zgc:136820
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to be involved in sarcomere organization. Predicted to be active in M band. Is expressed in trunk. Orthologous to human MYBPC2 (myosin binding protein C2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | MyBP-C, tri-helix bundle domain | Striated Muscle Structural and Regulatory Protein |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1JPV5 | InterPro | 822 | ||||||||||
| UniProtKB:Q0IJ38 | InterPro | 1120 | ||||||||||
| UniProtKB:A0A0R4IGP9 | InterPro | 1131 | ||||||||||
| UniProtKB:A0AB32TGP1 | InterPro | 1126 | ||||||||||
| UniProtKB:A0AB32TI80 | InterPro | 1125 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mybpc2a-201
(1)
|
Ensembl | 2,670 nt | ||
| mRNA |
mybpc2a-202
(1)
|
Ensembl | 3,759 nt | ||
| mRNA |
mybpc2a-203
(1)
|
Ensembl | 4,869 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-229O8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136545 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136820 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045859 (1) | 3784 nt | ||
| Genomic | GenBank:BX649540 (2) | 120836 nt | ||
| Polypeptide | UniProtKB:A0A0R4IGP9 (1) | 1131 aa |
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) FGF8 rescues motor deficits in zebrafish model of limb-girdle muscular dystrophy R18. Biochemical and Biophysical Research Communications. 652:768376-83
- Da'as, S.I., Hasan, W., Salem, R., Younes, N., Abdelrahman, D., Mohamed, I.A., Aldaalis, A., Temanni, R., Mathew, L.S., Lorenz, S., Yacoub, M., Nomikos, M., Nasrallah, G.K., Fakhro, K.A. (2022) Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model. International Journal of Molecular Sciences. 23(16)
- In Ka, H., Seo, H., Choi, Y., Kim, J., Cho, M., Choi, S.Y., Park, S., Han, S., An, J., Chung, H.S., Yang, Y., Kim, M.J. (2021) Loss of splicing factor IK impairs normal skeletal muscle development. BMC Biology. 19:44
- Li, Y.F., Canário, A.V.M., Power, D.M., Campinho, M.A. (2019) Ioxynil and diethylstilbestrol disrupt vascular and heart development in zebrafish. Environment International. 124:511-520
- Li, M., Andersson-Lendahl, M., Sejersen, T., Arner, A. (2016) Knockdown of fast skeletal myosin-binding protein C in zebrafish results in a severe skeletal myopathy. The Journal of general physiology. 147:309-22
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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