ZFIN ID: ZDB-GENE-060828-1
Gene Name: fibroblast growth factor 10b
Gene Symbol: fgf10b    Nomenclature History

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Previous Name: fgf25 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have fibroblast growth factor receptor binding activity and growth factor activity. Involved in animal organ development and ectodermal placode development. Predicted to localize to extracellular region. Is expressed in digestive system; lateral line system; mesoderm; pronephros; and tail bud. Human ortholog(s) of this gene implicated in LADD syndrome and aplasia of lacrimal and salivary glands. Orthologous to human FGF10 (fibroblast growth factor 10).
Genome Resources: Alliance (1),  Gene:751792 (1),  Ensembl(GRCz11):ENSDARG00000100475 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20345 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fgf10b N/A 1
    MO2-fgf10b N/A 1
    MO3-fgf10b N/A 1
    MO4-fgf10b N/A 1
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH fgf10b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    aplasia of lacrimal and salivary glands Alliance Aplasia of lacrimal and salivary glands 180920
    LADD syndrome Alliance LADD syndrome 149730
    DISEASE ASSOCIATED WITH fgf10b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ectodermal placode development (more)
    Cellular Component extracellular region (more)
    Molecular Function fibroblast growth factor receptor binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fgf10b No data available
    MARKER RELATIONSHIPS
    fgf10b Contained in: [BAC] DKEY-43L20 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001045858 (1) 564 nt
    Genomic GenBank:CR854981 (1) 169639 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4ITI2 (1) 191 aa
    Sequence Information (all 9)
    ORTHOLOGY for fgf10b ( Chr: 5 )
    CITATIONS (24)