Gene
fgf10b
- ID
- ZDB-GENE-060828-1
- Name
- fibroblast growth factor 10b
- Symbol
- fgf10b Nomenclature History
- Previous Names
-
- fgf25 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable chemoattractant activity; growth factor activity; and type 2 fibroblast growth factor receptor binding activity. Acts upstream of or within several processes, including liver development; otic vesicle development; and pancreas development. Predicted to be active in cytoplasm and extracellular space. Is expressed in digestive system; lateral line system; mesoderm; pronephros; and tail bud. Human ortholog(s) of this gene implicated in aplasia of lacrimal and salivary glands and lacrimoauriculodentodigital syndrome 3. Orthologous to human FGF10 (fibroblast growth factor 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa20345 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| aplasia of lacrimal and salivary glands | Alliance | Aplasia of lacrimal and salivary glands | 180920 |
| lacrimoauriculodentodigital syndrome 3 | Alliance | LADD syndrome 3 | 620193 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytokine IL1/FGF | Fibroblast growth factor family |
|---|---|---|---|---|
| UniProtKB:Q1XG75 | InterPro | 187 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
fgf10b-201
(1)
|
Ensembl | 1,739 nt | ||
| mRNA |
fgf10b-202
(1)
|
Ensembl | 564 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Cudak, N., López-Delgado, A.C., Keil, S., Knopf, F. (2023) Fibroblast growth factor pathway component expression in the regenerating zebrafish fin. Gene expression patterns : GEP. 48:119307
- Fabian, P., Tseng, K.C., Thiruppathy, M., Arata, C., Chen, H.J., Smeeton, J., Nelson, N., Crump, J.G. (2022) Lifelong single-cell profiling of cranial neural crest diversification in zebrafish. Nature communications. 13:13
- Bian, W.P., Pu, S.Y., Xie, S.L., Wang, C., Deng, S., Strauss, P.R., Pei, D.S. (2021) Loss of mpv17 affected early embryonic development via mitochondria dysfunction in zebrafish. Cell death discovery. 7:250
- Gallegos, T.F., Kamei, C.N., Rohly, M., Drummond, I.A. (2019) Fibroblast growth factor signaling mediates progenitor cell aggregation and nephron regeneration in the adult zebrafish kidney. Developmental Biology. 454(1):44-51
- Lush, M.E., Diaz, D.C., Koenecke, N., Baek, S., Boldt, H., St Peter, M.K., Gaitan-Escudero, T., Romero-Carvajal, A., Busch-Nentwich, E.M., Perera, A.G., Hall, K.E., Peak, A., Haug, J.S., Piotrowski, T. (2019) scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling. eLIFE. 8:
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Li, M., Page-McCaw, P., Chen, W. (2016) FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation. Diabetes. 65(1):96-109
- Shibata, E., Yokota, Y., Horita, N., Kudo, A., Abe, G., Kawakami, K., Kawakami, A. (2016) Fgf signalling controls diverse aspects of fin regeneration. Development (Cambridge, England). 143:2920-9
- Yan, C., Zheng, W., Gong, Z. (2015) Zebrafish fgf10b has a Complementary Function to fgf10a in Liver and Pancreas Development. Marine biotechnology (New York, N.Y.). 17(2):162-7
- Zhang, H., Wang, X., Lv, K., Gao, S., Wang, G., Fan, C., Zhang, X.A., Yan, J. (2015) Time Point-based Integrative Analyses of Deep-transcriptome Identify Four Signal Pathways in Blastemal Regeneration of Zebrafish Lower Jaw. Stem cells (Dayton, Ohio). 33(3):806-18
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