ZFIN ID: ZDB-GENE-060824-3
Gene Name: apobec1 complementation factor
Gene Symbol: a1cf    Nomenclature History

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Previous Name: acf (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have mRNA binding activity. Predicted to be involved in cytidine to uridine editing; mRNA localization resulting in posttranscriptional regulation of gene expression; and mRNA modification. Predicted to localize to the apolipoprotein B mRNA editing enzyme complex. Human ortholog(s) of this gene implicated in gout. Is expressed in liver. Orthologous to human A1CF (APOBEC1 complementation factor).
Genome Resources: Alliance (1),  Gene:562916 (1),  Ensembl(GRCz11):ENSDARG00000002968 (2)
GENE EXPRESSION
All Expression Data: 2 figures from Cheng et al., 2006
Wild-type Stages, Structures: Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH a1cf HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH a1cf VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process mRNA modification (more)
Cellular Component apolipoprotein B mRNA editing enzyme complex (more)
Molecular Function nucleic acid binding (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000504 RNA recognition motif domain
Family IPR006535 HnRNP R/Q splicing factor
Homologous_superfamily IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
Domain IPR014720 Double-stranded RNA-binding domain
Family IPR033111 APOBEC1 complementation factor
Domain IPR034539 ACF, RNA recognition motif 3
Homologous_superfamily IPR035979 RNA-binding domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA a1cf-201 (1)    Ensembl 2584
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM a1cf No data available
MARKER RELATIONSHIPS
a1cf Contained in: [BAC] CH211-215L11 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:XM_009306436 (1)
Genomic GenBank:BX248126 (1) 193490 bp
Select Tool
Polypeptide UniProtKB:R4GEC2 (1) 586 aa
Sequence Information (all 6)
ORTHOLOGY for a1cf ( Chr: 12 )
CITATIONS (19)