Gene
a1cf
- ID
- ZDB-GENE-060824-3
- Name
- apobec1 complementation factor
- Symbol
- a1cf Nomenclature History
- Previous Names
-
- acf (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable mRNA binding activity. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in liver. Human ortholog(s) of this gene implicated in gout. Orthologous to human A1CF (APOBEC1 complementation factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Cheng et al., 2006
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR014720 | Double-stranded RNA-binding domain |
| Domain | IPR044461 | A1CF, double-stranded RNA binding domain |
| Family | IPR006535 | HnRNP R/Q splicing factor |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | A1CF, double-stranded RNA binding domain | Double-stranded RNA-binding domain | HnRNP R/Q splicing factor | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3BE00 | InterPro | 550 | ||||||
| UniProtKB:A0AB32TZ00 | InterPro | 594 | ||||||
| UniProtKB:A0AB32U137 | InterPro | 586 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-215L11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068224697 (1) | 4834 nt | ||
| Genomic | GenBank:BX248126 (1) | 193490 nt | ||
| Polypeptide | UniProtKB:A0AB32TZ00 (1) | 594 aa |
- Vasconcelos, A.C.N., Streit, D.P., Octavera, A., Miwa, M., Kabeya, N., Yoshizaki, G. (2019) The germ cell marker dead end reveals alternatively spliced transcripts with dissimilar expression. Scientific Reports. 9:2407
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Nagasawa, K., Fernandes, J.M., Yoshizaki, G., Miwa, M., and Babiak, I. (2013) Identification and migration of primordial germ cells in Atlantic salmon, Salmo salar: Characterization of vasa, dead end, and lymphocyte antigen 75 genes. Molecular reproduction and development. 80(2):118-131
- Wang, Y., and Zhang, S. (2011) Identification and expression of liver-specific genes after LPS challenge in amphioxus: the hepatic cecum as liver-like organ and "pre-hepatic" acute phase response. Functional & integrative genomics. 11(1):111-118
- Sato, Y., Hashiguchi, Y., and Nishida, M. (2009) Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. BMC Evolutionary Biology. 9:127
- Cheng, W., Guo, L., Zhang, Z., Soo, H.M., Wen, C., Wu, W., and Peng, J. (2006) HNF factors form a network to regulate liver-enriched genes in zebrafish. Developmental Biology. 294(2):482-496
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