Gene
npm2a
- ID
- ZDB-GENE-060810-57
- Name
- nucleophosmin/nucleoplasmin, 2a
- Symbol
- npm2a Nomenclature History
- Previous Names
-
- im:7155659
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity; chromatin binding activity; and histone binding activity. Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within chromatin organization and single fertilization. Predicted to be located in nucleus. Predicted to be active in cytoplasm; nucleolus; and nucleoplasm. Is expressed in oocyte and unfertilized egg. Orthologous to human NPM2 (nucleophosmin/nucleoplasmin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7155659 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Cheung et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-npm2a | Cheung et al., 2018 | |
| CRISPR2-npm2a | Cheung et al., 2018 | |
| CRISPR3-npm2a | Cheung et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleoplasmin core domain | Nucleoplasmin core domain superfamily | Nucleoplasmin family |
|---|---|---|---|---|---|
| UniProtKB:B0UYT8 | InterPro | 156 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-215F19 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7155659 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001199913 (1) | 891 nt | ||
| Genomic | GenBank:CR749761 (1) | 206771 nt | ||
| Polypeptide | UniProtKB:B0UYT8 (1) | 156 aa |
- Cheung, C.T., Pasquier, J., Bouleau, A., Nguyen, T., Chesnel, F., Guiguen, Y., Bobe, J. (2018) Double maternal-effect: duplicated nucleoplasmin 2 genes, npm2a and npm2b, with essential but distinct functions are shared by fish and tetrapods. BMC Evolutionary Biology. 18:167
- Hou, J., Liu, H., Wang, L., Duan, L., Li, S., Wang, X. (2018) Molecular Toxicity of Metal Oxide Nanoparticles in Danio rerio. Environmental science & technology. 52(14):7996-8004
- Seigfried, F.A., Dietmann, P., Kühl, M., Kühl, S.J. (2018) Expression of the adhesion G protein-coupled receptor A2 (adgra2) during Xenopus laevis development. Gene expression patterns : GEP. 28:54-61
- Wotton, K.R., Weierud, F.K., Dietrich, S., and Lewis, K.E. (2008) Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates. BMC Evolutionary Biology. 8:171
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