Gene
mlh3
- ID
- ZDB-GENE-060810-45
- Name
- mutL homolog 3 (E. coli)
- Symbol
- mlh3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have ATPase activity. Predicted to be involved in mismatch repair. Predicted to localize to mismatch repair complex. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal cancer; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 7. Orthologous to human MLH3 (mutL homolog 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7152582 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| endometrial cancer | Alliance | {Endometrial cancer, susceptibility to} | 608089 |
| hereditary nonpolyposis colorectal cancer type 7 | Alliance | Colorectal cancer, hereditary nonpolyposis, type 7 | 614385 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013507 | DNA mismatch repair protein, S5 domain 2-like |
| Domain | IPR014790 | MutL, C-terminal, dimerisation |
| Family | IPR002099 | DNA mismatch repair protein MutL/Mlh/PMS |
| Family | IPR038973 | DNA mismatch repair protein MutL/Mlh/Pms-like |
| Homologous_superfamily | IPR014721 | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup |
| Homologous_superfamily | IPR020568 | Ribosomal protein uS5 domain 2-type superfamily |
| Homologous_superfamily | IPR036890 | Histidine kinase/HSP90-like ATPase superfamily |
| Homologous_superfamily | IPR037198 | MutL, C-terminal domain superfamily |
| Homologous_superfamily | IPR042120 | MutL, C-terminal domain, dimerisation subdomain |
| Homologous_superfamily | IPR042121 | MutL, C-terminal domain, regulatory subdomain |
Domain Details Per Protein
| Protein | Length | DNA mismatch repair protein MutL/Mlh/PMS | DNA mismatch repair protein MutL/Mlh/Pms-like | DNA mismatch repair protein, S5 domain 2-like | Histidine kinase/HSP90-like ATPase superfamily | MutL, C-terminal, dimerisation | MutL, C-terminal domain, dimerisation subdomain | MutL, C-terminal domain, regulatory subdomain | MutL, C-terminal domain superfamily | Ribosomal protein uS5 domain 2-type superfamily | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7T846
|
1043 | ||||||||||
|
UniProtKB:A0A8M2B931
|
1144 | ||||||||||
|
UniProtKB:A0A8M9PFG3
|
1043 | ||||||||||
|
UniProtKB:A0A8M9P5H1
|
1144 |
Interactions and Pathways
No data available
Plasmids
No data available