Gene

frmd5b

ID

ZDB-GENE-060810-165

Name

FERM domain containing 5b

Symbol

frmd5b Nomenclature History

Previous Names

frmd5
im:7161681

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to be involved in actomyosin structure organization. Predicted to be located in membrane. Predicted to be active in cytoskeleton. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with eye movement abnormalities and ataxia. Orthologous to human FRMD5 (FERM domain containing 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7161681 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With frmd5b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
neurodevelopmental disorder with eye movement abnormalities and ataxia	Alliance	Neurodevelopmental disorder with eye movement abnormalities and ataxia	620094

Associated With frmd5b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019747	FERM conserved site
Domain	IPR000299	FERM domain
Domain	IPR014847	FERM adjacent
Domain	IPR018979	FERM, N-terminal
Domain	IPR018980	FERM, C-terminal PH-like domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR014352	FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain

Domain Details Per Protein

Protein	Additional Resources	Length	Band 4.1 domain	FERM/acyl-CoA-binding protein superfamily	FERM adjacent	FERM central domain	FERM conserved site	FERM, C-terminal PH-like domain	FERM domain	FERM, N-terminal	FERM superfamily, second domain	PH-like domain superfamily	Ubiquitin-like domain superfamily
UniProtKB:E7F1C5	InterPro	571

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	frmd5b-202 (1) Ensembl	Ensembl	510 nt	Select Tool ZFIN BLAST
mRNA	frmd5b-201 (1) Ensembl	Ensembl	5,558 nt	Select Tool ZFIN BLAST
mRNA	frmd5b-205 (1) Ensembl	Ensembl	783 nt	Select Tool ZFIN BLAST
ncRNA	frmd5b-203 (1) Ensembl	Ensembl	695 nt	Select Tool ZFIN BLAST
ncRNA	frmd5b-204 (1) Ensembl	Ensembl	789 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations