Gene
wdr35
- ID
- ZDB-GENE-060810-148
- Name
- WD repeat domain 35
- Symbol
- wdr35 Nomenclature History
- Previous Names
-
- im:7159945 (1)
- si:ch211-206k20.4
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Acts upstream of or within cilium assembly. Predicted to be located in ciliary basal body and cytoplasm. Predicted to be part of intraciliary transport particle A. Predicted to be active in axoneme. Human ortholog(s) of this gene implicated in Ellis-Van Creveld syndrome; cranioectodermal dysplasia 2; and short-rib thoracic dysplasia 7 with or without polydactyly. Orthologous to human WDR35 (WD repeat domain 35).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7159945 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Stawicki et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
cranioectodermal dysplasia 2 | Alliance | Cranioectodermal dysplasia 2 | 613610 |
short-rib thoracic dysplasia 7 with or without polydactyly | Alliance | Short-rib thoracic dysplasia 7 with or without polydactyly | 614091 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR024977 | Anaphase-promoting complex subunit 4-like, WD40 domain |
Family | IPR017233 | WD repeat protein 35 |
Family | IPR039857 | Intraflagellar transport protein 122/121 homolog |
Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
Protein | Length | Anaphase-promoting complex subunit 4-like, WD40 domain | Intraflagellar transport protein 122/121 homolog | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | WD repeat protein 35 |
---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9Q9T9
|
1184 | ||||||
UniProtKB:B7ZD88
|
1203 |
Interactions and Pathways
No data available
Plasmids
No data available