ZFIN ID: ZDB-GENE-060803-2
Gene Name: integrin, beta 1a
Gene Symbol: itgb1a    Nomenclature History

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Previous Name: beta1-1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Exhibits fibronectin binding activity and protein heterodimerization activity. Predicted to contribute to C-X3-C chemokine binding activity and laminin binding activity. Involved in several processes, including atrioventricular valve morphogenesis; glial cell development; and positive regulation of sprouting angiogenesis. Predicted to localize to cell surface; focal adhesion; and integrin complex. Is expressed in several structures, including cardiovascular system; integument; liver; periderm; and pleuroperitoneal region. Orthologous to human ITGB1 (integrin subunit beta 1).
Genome Resources: Alliance (1),  Gene:556734 (1),  Ensembl(GRCz11):ENSDARG00000071863 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa8902 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24427 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24428 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30023 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-itgb1a
    1
    CRISPR2-itgb1a
    1
    MO1-itgb1a N/A 3
    DISEASE ASSOCIATED WITH itgb1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH itgb1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of sprouting angiogenesis (more)
    Cellular Component cell junction (more)
    Molecular Function protein heterodimerization activity (more)
    GO Terms (all 26)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA itgb1a-201 (1)    Ensembl 3414
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM itgb1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(UAS:mCherry-DNitgb1a) UAS itgb1amCherry Danio rerio 1 4
    MARKER RELATIONSHIPS
    itgb1a Contained in: [BAC] DKEYP-9D12 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001034971 (1) 2397 nt
    Genomic GenBank:BX322549 (1) 62252 nt
    Select Tool
    Polypeptide UniProtKB:A0A286Y9W0 (1) 802 aa
    Sequence Information (all 15)
    ORTHOLOGY for itgb1a ( Chr: 24 )
    CITATIONS (38)