Gene

scube3

ID

ZDB-GENE-060717-1

Name

signal peptide, CUB domain, EGF-like 3

Symbol

scube3 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity. Involved in skeletal muscle fiber development and smoothened signaling pathway. Predicted to localize to cell surface and extracellular space. Is expressed in several structures, including blastomere; central nervous system; optic cup; segmental plate; and solid lens vesicle. Orthologous to human SCUBE3 (signal peptide, CUB domain and EGF like domain containing 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Tsao et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With scube3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 2	Alliance	Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies	619184

Associated With scube3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR000859	CUB domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR011641	Tyrosine-protein kinase ephrin type A/B receptor-like
Domain	IPR024731	EGF domain
Domain	IPR026823	Complement Clr-like EGF domain
Domain	IPR049883	NOTCH1 EGF-like calcium-binding domain
Family	IPR052071	Signal peptide, CUB and EGF-like domain-containing protein
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR035914	Spermadhesin, CUB domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site

Domain Details Per Protein

Protein	Length	Complement Clr-like EGF domain	CUB domain	EGF domain	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	Growth factor receptor cysteine-rich domain superfamily	NOTCH1 EGF-like calcium-binding domain	Signal peptide, CUB and EGF-like domain-containing protein	Spermadhesin, CUB domain superfamily	Tyrosine-protein kinase ephrin type A/B receptor-like
UniProtKB:F1R0I7 InterPro	995
UniProtKB:A0A8M9PKI0 InterPro	1019

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	scube3-201 (1) Ensembl	Ensembl		3,190 nt	Select Tool ZFIN BLAST
mRNA	scube3-202 (1) Ensembl	Ensembl		3,259 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations