ZFIN ID: ZDB-GENE-060616-96
Gene Name: plasmalemma vesicle associated protein b
Gene Symbol: plvapb    Nomenclature History

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Previous Names: plvap, Dr.9655 (1), fb11a07, vsg1, wu:fb11a07, zgc:113451, zgc:136228 (1), zvsg1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Involved in Notch signaling pathway. Predicted to localize to integral component of membrane. Is expressed in vasculature. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human PLVAP (plasmalemma vesicle associated protein).
Genome Resources: Alliance (1),  Gene:570276 (1),  Ensembl(GRCz11):ENSDARG00000045003 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13080 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18400 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • DISEASE ASSOCIATED WITH plvapb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Diarrhea 10, protein-losing enteropathy type 618183
    DISEASE ASSOCIATED WITH plvapb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process Notch signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function molecular_function (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA plvapb-201 (1)    Ensembl 2019
    ncRNA vsg1-002 (1)    Ensembl 725
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM plvapb
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(plvapb:EGFP) plvapb EGFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    plvapb Contained in: [BAC] DKEY-67M7 (1) (order this)
    plvapb Encodes: [EST] fb11a07
    [cDNA] MGC:113451 (1), MGC:136228 (1), MGC:192924 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001030244 (1) 1982 nt
    Genomic GenBank:BX255969 (1) 155717 nt
    Select Tool
    Polypeptide UniProtKB:F1Q8W5 (1) 409 aa
    Sequence Information (all 21)
    ORTHOLOGY for plvapb ( Chr: 11 )
    CITATIONS (29)