arhgef1

ID

ZDB-GENE-060616-136

Name

Rho guanine nucleotide exchange factor (GEF) 1

Symbol

arhgef1 Nomenclature History

Previous Names

arhgef1b (1)
im:7155372
zgc:136551

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable G protein-coupled receptor binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within intracellular signal transduction. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including adaxial cell; immature eye; nervous system; neural plate; and pericardial region. Human ortholog(s) of this gene implicated in immunodeficiency 62. Orthologous to human ARHGEF1 (Rho guanine nucleotide exchange factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7155372 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency 62	Alliance	?Immunodeficiency 62	618459

Associated With arhgef1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain	IPR000219	Dbl homology domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR015212	Regulator of G protein signalling-like domain
Domain	IPR037887	p115RhoGEF, RGS domain
Domain	IPR041020	ARHGEF1-like, PH domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036305	RGS domain superfamily
Homologous_superfamily	IPR044926	RGS, subdomain 2

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9NZA7	InterPro	1071
UniProtKB:A0A8M9PMH6	InterPro	1002
UniProtKB:A0A8M6YTG6	InterPro	1061
UniProtKB:A0A8M9PD45	InterPro	1081
UniProtKB:A0A8M9PD48	InterPro	1026
UniProtKB:F1Q4Y0	InterPro	1005
UniProtKB:A0A8M9P7X6	InterPro	1053
UniProtKB:A0A8M9PJI7	InterPro	862
UniProtKB:A0A8M9P7X5	InterPro	1082
UniProtKB:A0A8M9PJI2	InterPro	1073
UniProtKB:A0A8M9PMH2	InterPro	1078
UniProtKB:A0AB32T845	InterPro	994
UniProtKB:A0AC58HGR8	InterPro	1077
UniProtKB:A0AC58HGS1	InterPro	1081
UniProtKB:A0AC58HGS3	InterPro	1057
UniProtKB:A0AC58HGS4	InterPro	1050
UniProtKB:A0AC58HGS5	InterPro	1066
UniProtKB:A0AC58HGS6	InterPro	1067
UniProtKB:A0AC58HGS7	InterPro	1045
UniProtKB:A0AC58HGS9	InterPro	1070
UniProtKB:A0AC58HGT1	InterPro	1056
UniProtKB:A0AC58HGT4	InterPro	991
UniProtKB:A0AC58HGT5	InterPro	1002
UniProtKB:A0AC58HGT6	InterPro	987
UniProtKB:A0AC58HGT7	InterPro	998
UniProtKB:A0AC58HGT8	InterPro	1046
UniProtKB:A0AC58HGT9	InterPro	993
UniProtKB:A0AC58HGU0	InterPro	1049
UniProtKB:A0AC58HGU1	InterPro	1004
UniProtKB:A0AC58HGU2	InterPro	946
UniProtKB:A0AC58HGU4	InterPro	858
UniProtKB:A0AC58HGU5	InterPro	986
UniProtKB:A0AC58HGU6	InterPro	1025
UniProtKB:A0AC58HGU7	InterPro	1014
UniProtKB:A0AC58HGU8	InterPro	1015
UniProtKB:A0AC58HGU9	InterPro	935
UniProtKB:A0AC58HGV1	InterPro	795
UniProtKB:A0AC58HGV4	InterPro	945
UniProtKB:A0AC58HGV6	InterPro	794
UniProtKB:A0AC58HGW1	InterPro	847
UniProtKB:A0AC58HGW9	InterPro	805
UniProtKB:A0AC58HGX1	InterPro	806