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ZIRC
ZFIN ID: ZDB-GENE-060608-2
Gene Name: solute carrier family 30 member 10
Gene Symbol: slc30a10    Nomenclature History

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Previous Name: ZnT10 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have cation transmembrane transporter activity. Involved in manganese ion homeostasis and manganese ion transport. Predicted to localize to the plasma membrane. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 1. Is expressed in brain; liver; and yolk syncytial layer. Orthologous to human SLC30A10 (solute carrier family 30 member 10).
Genome Resources: Alliance (1),  Gene:555724 (1),  Ensembl(GRCz11):ENSDARG00000103983 (1)
GENE EXPRESSION
All Expression Data: Fig. 1 from Xia et al., 2017
Wild-type Stages, Structures: Larval:Day 4 (96.0h-120.0h) to Larval:Day 6 (144.0h-168.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
zju11 Insertion Exon 1 Frameshift, Premature Stop CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zju12 Small Deletion Exon 1 Frameshift, Premature Stop CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-slc30a10
    1
    CRISPR2-slc30a10 1
    DISEASE ASSOCIATED WITH slc30a10 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hypermanganesemia with dystonia 1 Alliance Hypermanganesemia with dystonia 1 613280
    DISEASE ASSOCIATED WITH slc30a10 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process manganese ion homeostasis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function cation transmembrane transporter activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002524 (1)
  • InterPro:IPR027469 (1)
  • Pfam:PF01545 (1)
  • TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc30a10 No data available
    MARKER RELATIONSHIPS
    slc30a10 Encodes: [cDNA] MGC:171564 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128234 (1)
    Polypeptide UniProtKB:A0A0R4IEQ2 (1) 385 aa
    Sequence Clusters UniGene:110401 (1)
    Sequence Information (all 16)
    ORTHOLOGY for slc30a10 ( Chr: 13 )
    CITATIONS (112)