Gene
mtx1a
- ID
- ZDB-GENE-060606-2
- Name
- metaxin 1a
- Symbol
- mtx1a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to be involved in mitochondrion organization. Predicted to act upstream of or within protein transport. Predicted to be located in mitochondrial outer membrane. Predicted to be part of SAM complex. Predicted to be active in cytoplasm. Orthologous to human MTX1 (metaxin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Duan et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mtx1a | Duan et al., 2021 | |
| CRISPR2-mtx1a | Duan et al., 2021 | |
| CRISPR3-mtx1a | Duan et al., 2021 | |
| CRISPR4-mtx1a | Duan et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR019564 | Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain |
| Domain | IPR033468 | Metaxin, glutathione S-transferase domain |
| Family | IPR017410 | Mitochondrial outer membrane transport complex protein Metaxin 1/3 |
| Family | IPR040079 | Glutathione transferase family |
| Family | IPR050931 | Mitochondrial Protein Transport Metaxin |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Glutathione S-transferase, C-terminal domain superfamily | Glutathione transferase family | Metaxin, glutathione S-transferase domain | Mitochondrial outer membrane transport complex protein Metaxin 1/3 | Mitochondrial outer membrane transport complex Sam37/metaxin, N-terminal domain | Mitochondrial Protein Transport Metaxin |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A2THY5 | InterPro | 319 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-181D19 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128238 (1) | 3196 nt | ||
| Genomic | GenBank:CR854827 (2) | 198702 nt | ||
| Polypeptide | UniProtKB:A2THY5 (1) | 319 aa |
- Duan, A., Wang, H., Zhu, Y., Wang, Q., Zhang, J., Hou, Q., Xing, Y., Shi, J., Hou, J., Qin, Z., Chen, Z., Liu, Z., Yang, J. (2021) Chromatin architecture reveals cell type-specific target genes for kidney disease risk variants. BMC Biology. 19:38
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- McKenzie, P., Chadalavada, S.C., Bohrer, J., and Adams, J.C. (2006) Phylogenomic analysis of vertebrate thrombospondins reveals fish-specific paralogues, ancestral gene relationships and a tetrapod innovation. BMC Evolutionary Biology. 6(1):33
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