Gene

trpm3

ID

ZDB-GENE-060531-95

Name

transient receptor potential cation channel, subfamily M, member 3

Symbol

trpm3 Nomenclature History

Previous Names

si:dkey-201c13.4

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable monoatomic cation channel activity. Predicted to be involved in metal ion transport and monoatomic cation transmembrane transport. Predicted to act upstream of or within monoatomic ion transport; protein tetramerization; and transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain; eye; integument; neural crest cell; and solid lens vesicle. Human ortholog(s) of this gene implicated in cataract. Orthologous to human TRPM3 (transient receptor potential cation channel subfamily M member 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With trpm3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with hypotonia, dysmorphic facies, and skeletal anomalies, with or without seizures	620224
		?Cataract 50 with or without glaucoma	620253

Associated With trpm3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005821	Ion transport domain
Domain	IPR032415	TRPM, tetramerisation domain
Domain	IPR041491	TRPM, SLOG domain
Family	IPR050927	Transient receptor potential cation channel M
Homologous_superfamily	IPR037162	TRPM, tetramerisation domain superfamily

Domain Details Per Protein

Protein	Length	Ion transport domain	Transient receptor potential cation channel M	TRPM, SLOG domain	TRPM, tetramerisation domain	TRPM, tetramerisation domain superfamily
UniProtKB:A0A8M9Q448 InterPro	1771
UniProtKB:A0A8M2BJA5 InterPro	1721
UniProtKB:A0A8N7UR71 InterPro	1709
UniProtKB:A0A8M2BJ81 InterPro	1723
UniProtKB:A0A8M9QEL2 InterPro	1769
UniProtKB:A0A8M3B9Q3 InterPro	1747
UniProtKB:A0A8M9PKZ6 InterPro	1783
UniProtKB:A0A8M9PL01 InterPro	1757
UniProtKB:A0A8M9Q450 InterPro	1745
UniProtKB:A0A8M2BJC2 InterPro	1735
UniProtKB:F1QYX6 InterPro	1583
UniProtKB:A0A8M9Q9C9 InterPro	1759
UniProtKB:A0A8M9PYM3 InterPro	1757
UniProtKB:A0A8M3ASK4 InterPro	1735
UniProtKB:A0A8M9PYL7 InterPro	1771

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	trpm3-201 (1) Ensembl	Ensembl		4,752 nt	Select Tool ZFIN BLAST
mRNA	trpm3-202 (1) Ensembl	Ensembl		5,205 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations