Gene
fzd9a
- ID
- ZDB-GENE-060531-77
- Name
- frizzled class receptor 9a
- Symbol
- fzd9a Nomenclature History
- Previous Names
-
- si:dkey-189h5.4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable Wnt-protein binding activity. Predicted to be involved in canonical Wnt signaling pathway and non-canonical Wnt signaling pathway. Predicted to act upstream of or within cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in central nervous system. Orthologous to human FZD9 (frizzled class receptor 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fzd9a | Zebrafish Nomenclature Committee | |
| TALEN1-fzd9a | Zebrafish Nomenclature Committee |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Frizzled cysteine-rich domain superfamily | Frizzled domain | Frizzled/secreted frizzled-related protein | Frizzled/Smoothened, 7TM | GPCR, family 2-like, 7TM |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1RF02 | InterPro | 581 | |||||
| UniProtKB:A3QK10 | InterPro | 581 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-189H5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_003198686 (1) | 2637 nt | ||
| Genomic | GenBank:BX322606 (1) | 240928 nt | ||
| Polypeptide | UniProtKB:A0A8M1RF02 (1) | 581 aa |
- Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579
- Grainger, S., Nguyen, N., Richter, J., Setayesh, J., Lonquich, B., Oon, C.H., Wozniak, J.M., Barahona, R., Kamei, C.N., Houston, J., Carrillo-Terrazas, M., Drummond, I.A., Gonzalez, D., Willert, K., Traver, D. (2019) EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. Nature cell biology. 21(6):721-730
- Kamei, C.N., Gallegos, T.F., Liu, Y., Hukriede, N., Drummond, I.A. (2019) Wnt signaling mediates new nephron formation during zebrafish kidney regeneration. Development (Cambridge, England). 146(8):
- So, J., Khaliq, M., Evason, K., Ninov, N., Martin, B.L., Stainier, D.Y.R., Shin, D. (2017) Wnt/β-catenin signaling controls intrahepatic biliary network formation in zebrafish by regulating Notch activity. Hepatology (Baltimore, Md.). 67(6):2352-2366
- Coppola, U., Annona, G., D'Aniello, S., Ristoratore, F. (2016) Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. BMC Evolutionary Biology. 16:26
- Nikaido, M., Law, E.W., and Kelsh, R.N. (2013) A Systematic Survey of Expression and Function of Zebrafish frizzled Genes. PLoS One. 8(1):e54833
- Sarras, M.P., Leontovich, A.A., Olsen, A.S., and Intine, R.V. (2013) Impaired tissue regeneration corresponds with altered expression of developmental genes that persists in the metabolic memory state of diabetic zebrafish. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 21(2):320-328
- Ramachandran, R., Zhao, X.F., and Goldman, D. (2011) Ascl1a/Dkk/ beta -catenin signaling pathway is necessary and glycogen synthase kinase-3 beta inhibition is sufficient for zebrafish retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 108(38):15858-63
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