Gene

cacna1ba

ID

ZDB-GENE-060531-44

Name

calcium channel, voltage-dependent, N type, alpha 1B subunit, a

Symbol

cacna1ba Nomenclature History

Previous Names

cacna1b (1)
CACNA1Bb (1)
si:ch211-238e12.1 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable high voltage-gated calcium channel activity. Predicted to be involved in calcium ion import across plasma membrane and chemical synaptic transmission. Predicted to act upstream of or within calcium ion transmembrane transport and regulation of monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated calcium channel complex. Predicted to be active in neuronal cell body. Is expressed in atrium; brain; cardiac ventricle; and liver. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome and dystonia 23. Orthologous to human CACNA1B (calcium voltage-gated channel subunit alpha1 B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cacna1ba Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements	618497

Associated With cacna1ba Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005821	Ion transport domain
Domain	IPR014873	Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
Domain	IPR031649	Voltage-dependent L-type calcium channel, IQ-associated domain
Family	IPR002077	Voltage-dependent calcium channel, alpha-1 subunit
Family	IPR005447	Voltage-dependent calcium channel, N-type, alpha-1 subunit
Family	IPR050599	Voltage-dependent calcium channel alpha-1 subunit
Homologous_superfamily	IPR027359	Voltage-dependent channel domain superfamily

Domain Details Per Protein

Protein	Length	Ion transport domain	Voltage-dependent calcium channel alpha-1 subunit	Voltage-dependent calcium channel, alpha-1 subunit	Voltage-dependent calcium channel, alpha-1 subunit, IQ domain	Voltage-dependent calcium channel, N-type, alpha-1 subunit	Voltage-dependent channel domain superfamily	Voltage-dependent L-type calcium channel, IQ-associated domain
UniProtKB:A0A8M3AZM5 InterPro	2357
UniProtKB:A0A8M9Q3D8 InterPro	2365
UniProtKB:A0A8M6Z0K7 InterPro	2369
UniProtKB:A0A8M3ASG9 InterPro	2378
UniProtKB:T2B1R0 InterPro	2194
UniProtKB:A0A8M9Q3C7 InterPro	2376
UniProtKB:A0A8M3B9N2 InterPro	2351
UniProtKB:A0A8M9QE01 InterPro	2205
UniProtKB:A0A8M3B2I1 InterPro	2367
UniProtKB:A0A8M9PK68 InterPro	2344
UniProtKB:A0A8M9QDZ5 InterPro	2374
UniProtKB:A0A8M9Q8P2 InterPro	2346
UniProtKB:A0A8M6Z6W1 InterPro	2364
UniProtKB:A0A8M9PXN1 InterPro	2365
UniProtKB:A0A8M6YY83 InterPro	2355
UniProtKB:A0A8M9Q8N7 InterPro	2371
UniProtKB:A0A8M9PXL9 InterPro	2378
UniProtKB:A2BHF4 InterPro	2312

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cacna1ba-201 (1) Ensembl	Ensembl	6,939 nt	Select Tool ZFIN BLAST
mRNA	cacna1ba-202 (1) Ensembl	Ensembl	6,813 nt	Select Tool ZFIN BLAST
mRNA	cacna1ba-203 (1) Ensembl	Ensembl	6,585 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations