Gene
dnah10
- ID
- ZDB-GENE-060531-163
- Name
- dynein axonemal heavy chain 10
- Symbol
- dnah10 Nomenclature History
- Previous Names
-
- si:dkeyp-86b9.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Acts upstream of or within cilium movement and determination of left/right symmetry. Predicted to be located in cytoplasm and microtubule. Predicted to be part of dynein complex. Predicted to be active in 9+2 motile cilium. Is expressed in notochord. Used to study idiopathic scoliosis. Human ortholog(s) of this gene implicated in spermatogenic failure 56. Orthologous to human DNAH10 (dynein axonemal heavy chain 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Liu et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6980 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20435 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20436 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ut28 | Allele with one deletion | Exon 60 | Frameshift, Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dnah10 | Liu et al., 2018 | |
| CRISPR2-dnah10 | Wang et al., 2021 | |
| CRISPR3-dnah10 | Wang et al., 2021 | |
| CRISPR4-dnah10 | Wang et al., 2021 | |
| CRISPR5-dnah10 | Wang et al., 2021 | |
| MO1-dnah10 | N/A | Liu et al., 2018 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spermatogenic failure 56 | Alliance | Spermatogenic failure 56 | 619515 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR004273 | Dynein heavy chain region D6 P-loop domain |
| Domain | IPR013594 | Dynein heavy chain, tail |
| Domain | IPR013602 | Dynein heavy chain, linker |
| Domain | IPR024317 | Dynein heavy chain, AAA module D4 |
| Domain | IPR024743 | Dynein heavy chain, coiled coil stalk |
| Domain | IPR035699 | Dynein heavy chain, hydrolytic ATP-binding dynein motor region |
| Domain | IPR035706 | Dynein heavy chain, ATP-binding dynein motor region |
| Domain | IPR041228 | Dynein heavy chain, C-terminal domain |
| Domain | IPR041466 | Dynein heavy chain, AAA 5 extension domain |
| Domain | IPR041658 | Dynein heavy chain AAA lid domain |
| Domain | IPR054354 | Dynein 2 heavy chain 1, cytoplasmic, ATPase lid domain |
| Family | IPR026983 | Dynein heavy chain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR042219 | Dynein heavy chain AAA lid domain superfamily |
| Homologous_superfamily | IPR042222 | Dynein heavy chain, domain 2, N-terminal |
| Homologous_superfamily | IPR042228 | Dynein heavy chain, linker, subdomain 3 |
| Homologous_superfamily | IPR043157 | Dynein heavy chain, AAA1 domain, small subdomain |
| Homologous_superfamily | IPR043160 | Dynein heavy chain, C-terminal domain, barrel region |
Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | Dynein 2 heavy chain 1, cytoplasmic, ATPase lid domain | Dynein heavy chain | Dynein heavy chain, AAA1 domain, small subdomain | Dynein heavy chain, AAA 5 extension domain | Dynein heavy chain AAA lid domain | Dynein heavy chain AAA lid domain superfamily | Dynein heavy chain, AAA module D4 | Dynein heavy chain, ATP-binding dynein motor region | Dynein heavy chain, coiled coil stalk | Dynein heavy chain, C-terminal domain | Dynein heavy chain, C-terminal domain, barrel region | Dynein heavy chain, domain 2, N-terminal | Dynein heavy chain, hydrolytic ATP-binding dynein motor region | Dynein heavy chain, linker | Dynein heavy chain, linker, subdomain 3 | Dynein heavy chain region D6 P-loop domain | Dynein heavy chain, tail | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FGT8 | InterPro | 4626 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dnah10-201
(1)
|
Ensembl | 13,881 nt | ||
| mRNA |
dnah10-202
(1)
|
Ensembl | 12,789 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-86B9 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009301568 (1) | |||
| Genomic | GenBank:BX323557 (1) | 223754 nt | ||
| Polypeptide | UniProtKB:E7FGT8 (1) | 4626 aa |
- Comparative Orthology
- Alliance
- Wang, Y., Troutwine, B.R., Zhang, H., Gray, R.S. (2021) The axonemal dynein heavy chain 10 gene is essential for monocilia motility and spine alignment in zebrafish. Developmental Biology. 482:82-90
- Liu, C., Cao, R., Xu, Y., Li, T., Li, F., Chen, S., Xu, R., Sun, K. (2018) Rare copy number variants analysis identifies novel candidate genes in heterotaxy syndrome patients with congenital heart defects. Genome Medicine. 10:40
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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