Gene

mark4a

ID

ZDB-GENE-060531-156

Name

MAP/microtubule affinity-regulating kinase 4a

Symbol

mark4a Nomenclature History

Previous Names

sb:eu746
si:dkey-85k8.8

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction and microtubule cytoskeleton organization. Predicted to localize to cytoplasm. Orthologous to human MARK4 (microtubule affinity regulating kinase 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2005

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu746 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mark4a Human Ortholog

No data available

Associated With mark4a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001772	Kinase associated domain 1 (KA1)
Domain	IPR015940	Ubiquitin-associated domain
Domain	IPR049508	Serine/threonine-protein kinase MARK 1-4, catalytic domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR028375	KA1 domain/Ssp2, C-terminal

Domain Details Per Protein

Protein	Length	KA1 domain/Ssp2, C-terminal	Kinase associated domain 1 (KA1)	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	Serine/threonine-protein kinase MARK 1-4, catalytic domain	Ubiquitin-associated domain
UniProtKB:A0A8M2BCS1 InterPro	762
UniProtKB:A0A8M2BCN5 InterPro	758
UniProtKB:A0A8M9Q9J1 InterPro	693
UniProtKB:A0A8M9QER0 InterPro	697

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	mark4a-201 (1) Ensembl	Ensembl		2,211 nt	Select Tool ZFIN BLAST
mRNA	mark4a-202 (1) Ensembl	Ensembl		2,330 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations