Gene
htr5aa
- ID
- ZDB-GENE-060531-129
- Name
- 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate a
- Symbol
- htr5aa Nomenclature History
- Previous Names
-
- htr5a
- si:dkey-265a7.5
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in brain; inferior raphe nucleus; and optic tectum. Orthologous to human HTR5A (5-hydroxytryptamine receptor 5A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 5-hydroxytryptamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
| UniProtKB:A0A0R4IFY3 | InterPro | 345 | |||
| UniProtKB:A0AB32TS86 | InterPro | 291 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
htr5aa-201
(1)
|
Ensembl | 1,216 nt | ||
| mRNA |
htr5aa-202
(1)
|
Ensembl | 2,919 nt | ||
| mRNA |
htr5aa-203
(1)
|
Ensembl | 1,227 nt | ||
| mRNA |
htr5aa-204
(1)
|
Ensembl | 1,030 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-207D6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-265A7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162880 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001126410 (1) | 1227 nt | ||
| Genomic | GenBank:BX510360 (1) | 213323 nt | ||
| Polypeptide | UniProtKB:A0A0R4IFY3 (1) | 345 aa |
- Li, Y., Zhang, L., Mao, M., He, L., Wang, T., Pan, Y., Zhao, X., Li, Z., Mu, X., Qian, Y., Qiu, J. (2023) Multi-omics analysis of a drug-induced model of bipolar disorder in zebrafish. iScience. 26:106744106744
- García-González, J., Brock, A.J., Parker, M.O., Riley, R.J., Joliffe, D., Sudwarts, A., Teh, M.T., Busch-Nentwich, E.M., Stemple, D.L., Martineau, A.R., Kaprio, J., Palviainen, T., Kuan, V., Walton, R.T., Brennan, C.H. (2020) Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour. eLIFE. 9:
- Jia, M., Teng, M., Tian, S., Yan, J., Meng, Z., Yan, S., Li, R., Zhou, Z., Zhu, W. (2020) Developmental toxicity and neurotoxicity of penconazole enantiomers exposure on zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 267:115450
- Tian, J., Hu, J., Liu, D., Yin, J., Chen, M., Zhou, L., Yin, H. (2020) Cadmium chloride-induced transgenerational neurotoxicity in zebrafish development. Environmental Toxicology and Pharmacology. 81:103545
- Wu, Q., Yan, W., Cheng, H., Liu, C., Hung, T.C., Guo, X., Li, G. (2017) Parental transfer of microcystin-LR induced transgenerational effects of developmental neurotoxicity in zebrafish offspring. Environmental pollution (Barking, Essex : 1987). 231:471-478
- Kwan, W., Cortes, M., Frost, I., Esain, V., Theodore, L.N., Liu, S.Y., Budrow, N., Goessling, W., North, T.E. (2016) The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling. Cell Stem Cell. 19:370-82
- Pei, S., Liu, L., Zhong, Z., Wang, H., Lin, S., Shang, J. (2016) Risk of prenatal depression and stress treatment: alteration on serotonin system of offspring through exposure to Fluoxetine. Scientific Reports. 6:33822
- Sourbron, J., Schneider, H., Kecskés, A., Liu, Y., Buening, E.M., Lagae, L., Smolders, I., de Witte, P.A. (2016) Serotonergic Modulation as Effective Treatment for Dravet syndrome in a Zebrafish Mutant Model. ACS Chemical Neuroscience. 7(5):588-98
- Barreiro-Iglesias, A., Mysiak, K.S., Scott, A.L., Reimer, M.M., Yang, Y., Becker, C.G., Becker, T. (2015) Serotonin Promotes Development and Regeneration of Spinal Motor Neurons in Zebrafish. Cell Reports. 13:924-932
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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