Gene
drll.2
- ID
- ZDB-GENE-060531-125
- Name
- draculin-like, tandem duplicate 2
- Symbol
- drll.2 Nomenclature History
- Previous Names
-
- drl.2 (1)
- si:dkey-261j4.4
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in erythroid lineage cell; hematopoietic system; mesoderm; and presumptive mesoderm.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Pimtong et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa20563 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-drl,drll.1,drll.2 | (2) | |
| CRISPR1-drll | Zhang et al., 2022 | |
| CRISPR3-drl,drll.2 | Prummel et al., 2019 | |
| MO2-drl,drll.1,drll.2 | N/A | (2) |
| MO3-drl,drll.1,drll.2 | N/A | (2) |
| MO4-drl,drll.1,drll.2 | N/A | Karampelias et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C2H2-type Zinc-Finger Transcription Regulators | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|
| UniProtKB:B0R155 | InterPro | 411 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:dkey-261j4.4-201
(1)
|
Ensembl | 1,875 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-261J4 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001166446 (1) | |||
| Genomic | GenBank:AL935280 (1) | 221563 nt | ||
| Polypeptide | UniProtKB:B0R155 (1) | 411 aa |
No data available
- Hajiabadi, H., Mamontova, I., Prizak, R., Pancholi, A., Koziolek, A., Hilbert, L. (2022) Deep-learning microscopy image reconstruction with quality control reveals second-scale rearrangements in RNA polymerase II clusters. PNAS nexus. 1:pgac065pgac065
- Karampelias, C., Watt, K., Mattsson, C.L., Ruiz, Á.F., Rezanejad, H., Mi, J., Liu, X., Chu, L., Locasale, J.W., Korbutt, G.S., Rovira, M., Larsson, O., Andersson, O. (2022) MNK2 deficiency potentiates β-cell regeneration via translational regulation. Nature Chemical Biology. 18(9):942-953
- Zhang, X., Yang, Y., Wei, Y., Zhao, Q., Lou, X. (2022) Blf and drl cluster synergistically regulate cell fate commitment during zebrafish primitive hematopoiesis. Development (Cambridge, England). 149(24)
- Kobayashi, I., Kobayashi-Sun, J., Hirakawa, Y., Ouchi, M., Yasuda, K., Kamei, H., Fukuhara, S., Yamaguchi, M. (2019) Dual role of Jam3b in early hematopoietic and vascular development. Development (Cambridge, England). 147(1):
- Prummel, K.D., Hess, C., Nieuwenhuize, S., Parker, H.J., Rogers, K.W., Kozmikova, I., Racioppi, C., Brombacher, E.C., Czarkwiani, A., Knapp, D., Burger, S., Chiavacci, E., Shah, G., Burger, A., Huisken, J., Yun, M.H., Christiaen, L., Kozmik, Z., Müller, P., Bronner, M., Krumlauf, R., Mosimann, C. (2019) A conserved regulatory program initiates lateral plate mesoderm emergence across chordates. Nature communications. 10:3857
- Pimtong, W., Datta, M., Ulrich, A.M., Rhodes, J. (2014) Drl.3 governs primitive hematopoiesis in zebrafish. Scientific Reports. 4:5791
- Sumanas, S., Zhang, B., Dai, R., and Lin, S. (2005) 15-Zinc finger protein Bloody Fingers is required for zebrafish morphogenetic movements during neurulation. Developmental Biology. 283(1):85-96
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