Gene
drll.1
- ID
- ZDB-GENE-060531-124
- Name
- draculin-like, tandem duplicate 1
- Symbol
- drll.1 Nomenclature History
- Previous Names
-
- drl.1 (1)
- si:dkey-261j4.3
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in hematopoietic system and intermediate cell mass of mesoderm.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Pimtong et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-drl,drll.1,drll.2 | (2) | |
| CRISPR1-drll | Zhang et al., 2022 | |
| MO2-drl,drll.1,drll.2 | N/A | (2) |
| MO3-drl,drll.1,drll.2 | N/A | (2) |
| MO4-drl,drll.1,drll.2 | N/A | Karampelias et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type | Zinc finger protein, C2H2-type |
|---|---|---|---|---|---|
| UniProtKB:B0R154 | InterPro | 411 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:dkey-261j4.3-201
(1)
|
Ensembl | 1,878 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-261J4 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001166445 (1) | |||
| Genomic | GenBank:AL935280 (1) | 221563 nt | ||
| Polypeptide | UniProtKB:B0R154 (1) | 411 aa |
No data available
- Karampelias, C., Watt, K., Mattsson, C.L., Ruiz, Á.F., Rezanejad, H., Mi, J., Liu, X., Chu, L., Locasale, J.W., Korbutt, G.S., Rovira, M., Larsson, O., Andersson, O. (2022) MNK2 deficiency potentiates β-cell regeneration via translational regulation. Nature Chemical Biology. 18(9):942-953
- Zhang, X., Yang, Y., Wei, Y., Zhao, Q., Lou, X. (2022) Blf and drl cluster synergistically regulate cell fate commitment during zebrafish primitive hematopoiesis. Development (Cambridge, England). 149(24)
- Murat El Houdigui, S., Adam-Guillermin, C., Armant, O. (2020) Ionising Radiation Induces Promoter DNA Hypomethylation and Perturbs Transcriptional Activity of Genes Involved in Morphogenesis during Gastrulation in Zebrafish. International Journal of Molecular Sciences. 21(11)
- Kobayashi, I., Kobayashi-Sun, J., Hirakawa, Y., Ouchi, M., Yasuda, K., Kamei, H., Fukuhara, S., Yamaguchi, M. (2019) Dual role of Jam3b in early hematopoietic and vascular development. Development (Cambridge, England). 147(1):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Pimtong, W., Datta, M., Ulrich, A.M., Rhodes, J. (2014) Drl.3 governs primitive hematopoiesis in zebrafish. Scientific Reports. 4:5791
- Sumanas, S., Zhang, B., Dai, R., and Lin, S. (2005) 15-Zinc finger protein Bloody Fingers is required for zebrafish morphogenetic movements during neurulation. Developmental Biology. 283(1):85-96
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