Gene
htr7c
- ID
- ZDB-GENE-060526-5
- Name
- 5-hydroxytryptamine (serotonin) receptor 7c
- Symbol
- htr7c Nomenclature History
- Previous Names
-
- si:ch211-10p21.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Predicted to act upstream of or within several processes, including circadian rhythm; smooth muscle contraction; and vasoconstriction. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sourbron et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zf3759 | Allele with one delins | Exon 1 | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 5-Hydroxytryptamine 7 receptor | 5-hydroxytryptamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IHZ4 | InterPro | 400 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-10P21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-88F5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002661973 (1) | |||
| Genomic | GenBank:AL928864 (2) | 144433 nt | ||
| Polypeptide | UniProtKB:A0A0R4IHZ4 (1) | 400 aa |
No data available
- Gonçalves, C., Kareklas, K., Teles, M.C., Varela, S.A.M., Costa, J., Leite, R.B., Paixão, T., Oliveira, R.F. (2022) Phenotypic architecture of sociality and its associated genetic polymorphisms in zebrafish. Genes, brain, and behavior. 21(5):e12809
- Huang, C.X., Zhao, Y., Mao, J., Wang, Z., Xu, L., Cheng, J., Guan, N.N., Song, J. (2021) An injury-induced serotonergic neuron subpopulation contributes to axon regrowth and function restoration after spinal cord injury in zebrafish. Nature communications. 12:7093
- Sourbron, J., Schneider, H., Kecskés, A., Liu, Y., Buening, E.M., Lagae, L., Smolders, I., de Witte, P.A. (2016) Serotonergic Modulation as Effective Treatment for Dravet syndrome in a Zebrafish Mutant Model. ACS Chemical Neuroscience. 7(5):588-98
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