spef2

ID

ZDB-GENE-060526-47

Name

sperm flagellar 2

Symbol

spef2 Nomenclature History

Previous Names

si:ch211-149f21.2

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to be involved in sperm axoneme assembly. Predicted to be located in motile cilium. Predicted to be active in manchette and sperm midpiece. Human ortholog(s) of this gene implicated in spermatogenic failure 43. Orthologous to human SPEF2 (sperm flagellar 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With spef2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spermatogenic failure 43	Alliance	Spermatogenic failure 43	618751

Associated With spef2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001715	Calponin homology domain
Domain	IPR010441	CH-like domain in sperm protein
Domain	IPR054517	CPC1/SPEF2 domain D5
Domain	IPR056199	SPEF2, C-terminal domain
Family	IPR052634	Sperm flagellar development and bone growth associated protein
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036872	CH domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M3AZ97	InterPro	1703
UniProtKB:A0A8M3B259	InterPro	1704
UniProtKB:A0A8M3AS40	InterPro	1705
UniProtKB:A0A8M3B9C1	InterPro	1107
UniProtKB:A0A8M3ARW9	InterPro	1625
UniProtKB:A0A0R4IPA7	InterPro	1639