Gene
arhgap35b
- ID
- ZDB-GENE-060526-44
- Name
- Rho GTPase activating protein 35b
- Symbol
- arhgap35b Nomenclature History
- Previous Names
-
- arhgap35
- si:ch211-139a5.8
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Predicted to be involved in Rho protein signal transduction; regulation of axonogenesis; and regulation of cell size. Predicted to act upstream of or within signal transduction. Predicted to be located in several cellular components, including cytoskeleton; nucleus; and plasma membrane. Predicted to be active in cytosol. Orthologous to human ARHGAP35 (Rho GTPase activating protein 35).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Lippincott et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lippincott et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | FF domain | FF domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Rho GTPase-activating domain-containing protein | Rho GTPase-activating protein domain | Rho GTPase-activating protein, FF domain | Rho GTPase-activating protein, pG1 and pG2 domain | Rho GTPase-activating protein, pG1 domain | Rho GTPase-activating protein, pG2 domain | Rho GTPase activation protein | Small GTPase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A5PF53 | InterPro | 1517 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgap35b-201
(1)
|
Ensembl | 7,912 nt | ||
| mRNA |
arhgap35b-202
(1)
|
Ensembl | 877 nt | ||
| mRNA |
arhgap35b-203
(1)
|
Ensembl | 4,795 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-69I14 | ZFIN Curated Data | |
| Contained in | BAC | CH211-139A5 | ZFIN Curated Data | |
| Encodes | EST | wz10815 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001082843 (1) | |||
| Genomic | GenBank:AL935065 | 167740 nt | ||
| Polypeptide | UniProtKB:A5PF53 (1) | 1517 aa |
- Lippincott, M.F., Xu, W., Smith, A.A., Miao, X., Lafont, A., Shennib, O., Farley, G.J., Sabbagh, R., Delaney, A., Stamou, M., Plummer, L., Salnikov, K., Georgopoulos, N.A., Mericq, V., Quinton, R., Mau-Them, F.T., Nambot, S., Hamad, A., Brittain, H., Tooze, R.S., Calpena, E., Wilkie, A.O.M., Willems, M., Crowley, W.F., Balasubramanian, R., Lamarche-Vane, N., Davis, E.E., Seminara, S.B. (2022) The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay. Genetics in medicine : official journal of the American College of Medical Genetics. 24(12):2501-2515
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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