Gene
drd7
- ID
- ZDB-GENE-060526-372
- Name
- dopamine receptor D7
- Symbol
- drd7 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gs. Predicted to be involved in G protein-coupled dopamine receptor signaling pathway; adenylate cyclase-activating adrenergic receptor signaling pathway; and positive regulation of MAPK cascade. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Shontz et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa33609 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Dopamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|
|
UniProtKB:A3KPR9
|
443 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-38H2 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113643 (1) | |||
| Genomic | GenBank:BX323062 (1) | 199133 nt | ||
| Polypeptide | UniProtKB:A3KPR9 (1) | 443 aa |
No data available
- Roche, J., Hergalant, S., Depp, A., Ben Ammar, I., Lafont, A.G., Policar, T., Fontaine, P., Milla, S. (2020) First identification of dopamine receptors in pikeperch, Sander lucioperca, during the pre-ovulatory period. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 36:100747
- Opazo, J.C., Zavala, K., Miranda-Rottmann, S., Araya, R. (2018) Evolution of dopamine receptors: phylogenetic evidence suggests a later origin of the DRD2l and DRD4rs dopamine receptor gene lineages. PeerJ. 6:e4593
- Shontz, E.C., Souders Ii, C.L., Schmidt, J.T., Martyniuk, C.J. (2018) Domperidone up-regulates dopamine receptor expression and stimulates locomotor activity in larval zebrafish (Danio rerio). Genes, brain, and behavior. 17(4):e12460
- Wang, X.H., Zheng, S.S., Huang, T., Su, L.M., Zhao, Y.H., Souders, C.L., Martyniuk, C.J. (2018) Fluazinam impairs oxidative phosphorylation and induces hyper/hypo-activity in a dose specific manner in zebrafish larvae. Chemosphere. 210:633-644
- Wang, X.H., Souders, C.L., Zhao, Y.H., Martyniuk, C.J. (2017) Paraquat affects mitochondrial bioenergetics, dopamine system expression, and locomotor activity in zebrafish (Danio rerio). Chemosphere. 191:106-117
- Yamamoto, K., Mirabeau, O., Bureau, C., Blin, M., Michon-Coudouel, S., Demarque, M., and Vernier, P. (2013) Evolution of dopamine receptor genes of the D1 class in vertebrates. Mol. Biol. Evol.. 30(4):833-843
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