Gene
m17
- ID
- ZDB-GENE-060526-368
- Name
- IL-6 subfamily cytokine M17
- Symbol
- m17 Nomenclature History
- Previous Names
-
- leukemia inhibitory factor
- lif
- si:dkeyp-15f12.5
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable ciliary neurotrophic factor receptor binding activity; cytokine activity; and growth factor activity. Predicted to be involved in several processes, including astrocyte activation; cell surface receptor signaling pathway; and positive regulation of axon regeneration. Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be located in cytoplasm and membrane. Predicted to be active in axon; glial cell projection; and neuronal cell body. Is expressed in several structures, including brain; cranial ganglion; eye; pleuroperitoneal region; and presumptive neural retina. Human ortholog(s) of this gene implicated in Huntington's disease; disease of mental health; glaucoma; multiple sclerosis; and obesity. Orthologous to human CNTF (ciliary neurotrophic factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-m17 | (2) | |
| CRISPR2-m17 | (2) | |
| MO1-m17 | N/A | (2) |
| MO2-m17 | N/A | Wong et al., 2013 |
| MO3-m17 | N/A | Ogai et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ciliary neurotrophic factor, CNTF | Four-helical cytokine-like, core |
|---|---|---|---|---|
| UniProtKB:A0PAS6 | InterPro | 215 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-169J7 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001079833 (1) | 736 nt | ||
| Genomic | GenBank:BX004981 (1) | 162525 nt | ||
| Polypeptide | UniProtKB:A0PAS6 (1) | 215 aa |
No data available
- Boyd, P., Campbell, L.J., Hyde, D.R. (2023) Clcf1/Crlf1a-mediated signaling is neuroprotective and required for Müller glia proliferation in the light-damaged zebrafish retina. Frontiers in cell and developmental biology. 11:11425861142586
- Zhang, C., Zhao, Z., Jia, Y.J., Zhang, P.Q., Sun, Y., Zhou, Y.C., Wang, G.X., Zhu, B. (2023) Rationally Designed Self-Assembling Nanovaccines Elicit Robust Mucosal and Systemic Immunity against Rhabdovirus. ACS applied materials & interfaces. 16(1):228-244
- Shin, K., Begeman, I.J., Cao, J., Kang, J. (2022) leptin b and its regeneration enhancer illustrate the regenerative features of zebrafish hearts. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(1):91-106
- Zhang, W., Chen, L., Feng, H., Wang, J., Zeng, F., Xiao, X., Jian, J., Wang, N., Pang, H. (2022) Functional characterization of Vibrio alginolyticus T3SS regulator ExsA and evaluation of its mutant as a live attenuated vaccine candidate in zebrafish (Danio rerio) model. Frontiers in veterinary science. 9:938822938822
- Allanki, S., Strilic, B., Scheinberger, L., Onderwater, Y.L., Marks, A., Günther, S., Preussner, J., Kikhi, K., Looso, M., Stainier, D.Y.R., Reischauer, S. (2021) Interleukin-11 signaling promotes cellular reprogramming and limits fibrotic scarring during tissue regeneration. Science advances. 7:eabg6497
- Klatt Shaw, D., Mokalled, M.H. (2021) Efficient CRISPR/Cas9 mutagenesis for neurobehavioral screening in adult zebrafish. G3 (Bethesda). 11(8):
- Klatt Shaw, D., Saraswathy, V.M., Zhou, L., McAdow, A.R., Burris, B., Butka, E., Morris, S.A., Dietmann, S., Mokalled, M.H. (2021) Localized EMT reprograms glial progenitors to promote spinal cord repair. Developmental Cell. 56(5):613-626.e7
- Zhang, F., Han, L., Wang, J., Shu, M., Liu, K., Zhang, Y., Hsiao, C., Tian, Q., He, Q. (2021) Clozapine Induced Developmental and Cardiac Toxicity on Zebrafish Embryos by Elevating Oxidative Stress. Cardiovascular Toxicology. 21(5):399-409
- Cao, J., Feng, C., Xie, L., Li, L., Chen, J., Yun, S., Guo, W., Wang, T., Wu, Y., Meng, R., Wang, G., He, X., Luo, Y. (2020) Sesamin attenuates histological alterations, oxidative stress and expressions of immune-related genes in liver of zebrafish (Danio rerio) exposed to fluoride. Fish & shellfish immunology. 106:715-723
- Maselli, K.M., Gee, K., Grikscheit, T.C. (2020) Remnant Intestinal Length Defines Intestinal Adaptation and Hepatic Steatosis: Two Zebrafish Models. The Journal of surgical research. 255:86-95
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