Gene
m17
- ID
- ZDB-GENE-060526-368
- Name
- IL-6 subfamily cytokine M17
- Symbol
- m17 Nomenclature History
- Previous Names
-
- leukemia inhibitory factor
- lif
- si:dkeyp-15f12.5
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable ciliary neurotrophic factor receptor binding activity; cytokine activity; and growth factor activity. Predicted to be involved in several processes, including astrocyte activation; cell surface receptor signaling pathway; and positive regulation of axon regeneration. Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be located in cytoplasm and membrane. Predicted to be active in axon; glial cell projection; and neuronal cell body. Is expressed in several structures, including brain; cranial ganglion; eye; pleuroperitoneal region; and presumptive neural retina. Human ortholog(s) of this gene implicated in Huntington's disease; disease of mental health; glaucoma; multiple sclerosis; and obesity. Orthologous to human CNTF (ciliary neurotrophic factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Ciliary neurotrophic factor, CNTF | Four-helical cytokine-like, core |
|---|---|---|---|
|
UniProtKB:A0PAS6
|
215 |
Interactions and Pathways
No data available
Plasmids
No data available