Gene

cfap251

ID

ZDB-GENE-060526-328

Name

cilia and flagella associated protein 251

Symbol

cfap251 Nomenclature History

Previous Names

si:dkey-65b12.4 (1)
wdr66

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Acts upstream of or within neutrophil differentiation and thrombocyte differentiation. Predicted to be active in sperm flagellum. Human ortholog(s) of this gene implicated in spermatogenic failure 33. Orthologous to human CFAP251 (cilia and flagella associated protein 251).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Bielczyk-Maczyńska et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cfap251 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spermatogenic failure 33	Alliance	Spermatogenic failure 33	618152

Associated With cfap251 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR050630	WD repeat Echinoderm Microtubule-associated Protein-like
Homologous_superfamily	IPR011047	Quinoprotein alcohol dehydrogenase-like superfamily
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	EF-hand domain pair	Quinoprotein alcohol dehydrogenase-like superfamily	WD40 repeat	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily	WD repeat Echinoderm Microtubule-associated Protein-like
UniProtKB:A0A8M9PR50 InterPro	917
UniProtKB:A0A2R8RY46 InterPro	963
UniProtKB:A0A8M9Q1S6 InterPro	537
UniProtKB:F1Q8Y1 InterPro	963

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	wdr66-201 (1) Ensembl	Ensembl	2,892 nt	Select Tool ZFIN BLAST
mRNA	wdr66-203 (1) Ensembl	Ensembl	2,721 nt	Select Tool ZFIN BLAST
ncRNA	wdr66-002 (1) Ensembl	Ensembl	801 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations