Gene
alkbh2
- ID
- ZDB-GENE-060526-327
- Name
- alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
- Symbol
- alkbh2 Nomenclature History
- Previous Names
-
- si:dkey-65b12.2
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable broad specificity oxidative DNA demethylase activity; cytosine C-5 DNA demethylase activity; and ferrous iron binding activity. Predicted to be involved in DNA alkylation repair. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleolus and nucleoplasm. Orthologous to human ALKBH2 (alkB homolog 2, alpha-ketoglutarate dependent dioxygenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005123 | Oxoglutarate/iron-dependent dioxygenase domain |
| Domain | IPR027450 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
| Family | IPR032852 | DNA oxidative demethylase ALKBH2 |
| Homologous_superfamily | IPR037151 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha-ketoglutarate-dependent dioxygenase AlkB-like | Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily | DNA oxidative demethylase ALKBH2 | Oxoglutarate/iron-dependent dioxygenase domain |
|---|---|---|---|---|---|---|
| UniProtKB:A3QK41 | InterPro | 258 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
alkbh2-201
(1)
|
Ensembl | 999 nt |
Interactions and Pathways
No data available
Plasmids
No data available